230748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 84093..85003 Replicon plasmid pA
Accession NZ_CP090433
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPN857

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag LZ608_RS27260 Protein ID WP_004026354.1
Coordinates 84093..84563 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag LZ608_RS27265 Protein ID WP_004026357.1
Coordinates 84560..85003 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ608_RS27220 (LZ608_27220) 79409..79723 + 315 WP_011251273.1 hypothetical protein -
LZ608_RS27225 (LZ608_27225) 79732..80226 + 495 WP_011251274.1 hypothetical protein -
LZ608_RS27230 (LZ608_27230) 80232..80672 + 441 WP_011251275.1 hypothetical protein -
LZ608_RS27235 (LZ608_27235) 81097..82053 - 957 WP_011251280.1 DsbA family protein -
LZ608_RS27240 (LZ608_27240) 82113..82454 - 342 WP_011251281.1 hypothetical protein -
LZ608_RS27245 (LZ608_27245) 82468..82779 - 312 WP_011251282.1 hypothetical protein -
LZ608_RS27250 (LZ608_27250) 82796..83245 - 450 WP_011251283.1 thioredoxin fold domain-containing protein -
LZ608_RS27260 (LZ608_27260) 84093..84563 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
LZ608_RS27265 (LZ608_27265) 84560..85003 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
LZ608_RS27270 (LZ608_27270) 85104..85607 - 504 Protein_97 DUF4113 domain-containing protein -
LZ608_RS27275 (LZ608_27275) 85813..86793 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
LZ608_RS27280 (LZ608_27280) 86859..88166 + 1308 Protein_99 FepA family TonB-dependent siderophore receptor -
LZ608_RS27285 (LZ608_27285) 88228..88449 + 222 WP_004213615.1 hypothetical protein -
LZ608_RS27290 (LZ608_27290) 88793..89755 - 963 WP_004902373.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / iucA / iucB / iucC / iucD / iutA / rmpA2 1..192941 192941
- inside IScluster/Tn - iroN 77812..91404 13592


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T230748 WP_004026354.1 NZ_CP090433:c84563-84093 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T230748 NZ_CP125351:c747220-747068 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT230748 WP_004026357.1 NZ_CP090433:c85003-84560 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT230748 NZ_CP125351:747269-747326 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References