Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 883632..884286 Replicon chromosome
Accession NZ_CP090432
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPN857

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LZ608_RS04460 Protein ID WP_004144731.1
Coordinates 883879..884286 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LZ608_RS04455 Protein ID WP_002916312.1
Coordinates 883632..883898 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ608_RS04430 (LZ608_04430) 878788..880221 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LZ608_RS04435 (LZ608_04435) 880340..881068 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LZ608_RS04440 (LZ608_04440) 881118..881429 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LZ608_RS04445 (LZ608_04445) 881593..882252 + 660 WP_002916317.1 hemolysin III family protein -
LZ608_RS04450 (LZ608_04450) 882403..883386 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LZ608_RS04455 (LZ608_04455) 883632..883898 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LZ608_RS04460 (LZ608_04460) 883879..884286 + 408 WP_004144731.1 protein YgfX Toxin
LZ608_RS04465 (LZ608_04465) 884293..884814 - 522 WP_002916308.1 flavodoxin FldB -
LZ608_RS04470 (LZ608_04470) 884915..885811 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LZ608_RS04475 (LZ608_04475) 885834..886547 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZ608_RS04480 (LZ608_04480) 886553..888286 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T230730 WP_004144731.1 NZ_CP090432:883879-884286 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T230730 NZ_CP125346:c26048-25899 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230730 WP_002916312.1 NZ_CP090432:883632-883898 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230730 NZ_CP125346:26093-26152 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References