Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1414294..1414968 Replicon chromosome
Accession NC_011206
Organism Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)


Gene name vapC Uniprot ID B7JBN6
Locus tag LFERR_RS07210 Protein ID WP_009564531.1
Coordinates 1414549..1414968 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B7JBN5
Locus tag LFERR_RS07205 Protein ID WP_012536752.1
Coordinates 1414294..1414548 (+) Length 85 a.a.

Genomic Context

LFERR_RS07195LFERR_RS07200LFERR_RS07205LFERR_RS07210LFERR_RS07215LFERR_RS14930LFERR_RS07220LFERR_RS07225LFERR_RS07190
Location: 1411112..1412572 (1461 bp)
Type: Others
Protein ID: WP_012536750.1
Location: 1412576..1414120 (1545 bp)
Type: Others
Protein ID: WP_012536751.1
Location: 1414294..1414548 (255 bp)
Type: Antitoxin
Protein ID: WP_012536752.1
Location: 1414549..1414968 (420 bp)
Type: Toxin
Protein ID: WP_009564531.1
Location: 1414986..1415198 (213 bp)
Type: Others
Protein ID: WP_009564530.1
Location: 1415198..1415320 (123 bp)
Type: Others
Protein ID: Protein_1438
Location: 1416033..1417652 (1620 bp)
Type: Others
Protein ID: WP_012536754.1
Location: 1417743..1418942 (1200 bp)
Type: Others
Protein ID: WP_012536755.1
Location: 1409969..1410973 (1005 bp)
Type: Others
Protein ID: WP_012536749.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFERR_RS071901409969..1410973-1005WP_012536749.1glycosyltransferase family 2 protein-
LFERR_RS071951411112..1412572+1461WP_012536750.1IMP dehydrogenase-
LFERR_RS072001412576..1414120+1545WP_012536751.1glutamine-hydrolyzing GMP synthase-
LFERR_RS072051414294..1414548+255WP_012536752.1plasmid stabilization proteinAntitoxin
LFERR_RS072101414549..1414968+420WP_009564531.1type II toxin-antitoxin system VapC family toxinToxin
LFERR_RS072151414986..1415198+213WP_009564530.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
LFERR_RS149301415198..1415320+123Protein_1438VapC toxin family PIN domain ribonuclease-
LFERR_RS072201416033..1417652+1620WP_012536754.1APC family permease-
LFERR_RS072251417743..1418942+1200WP_012536755.1glutamate 5-kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14968.11 Da        Isoelectric Point: 4.7051

>T23073 WP_009564531.1 NC_011206:1414549-1414968 [Acidithiobacillus ferrooxidans ATCC 53993]
MIVLDTNVVSEAMKPEPDAAVRAWLNEQAAETLYLSSVTLAELLFGIRALPAGKCKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVTVINPWKDA

Download         Length: 420 bp

>T23073 NC_011206:1414549-1414968 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGATCGTCCTGGATACCAACGTCGTTTCCGAGGCGATGAAGCCGGAGCCAGACGCGGCCGTGAGGGCTTGGCTGAACGA
ACAGGCGGCGGAAACCTTGTATCTGTCGAGCGTCACGCTGGCCGAGTTGCTGTTCGGCATCCGGGCGCTGCCGGCGGGCA
AGTGCAAGAACATGCTCGACCGCGCCCTGACCGAACTGCTGGAGCTGTTCAAGGATCGGGTGCTGCCCTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCTGTTGCCGCATCGCGGGGCTTCATCGTGGCATCACGCGACACGTCGCCCTATGAAGCGGCCGGCGTGACCGTCATCA
ATCCCTGGAAGGATGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9225.67 Da        Isoelectric Point: 10.7239

>AT23073 WP_012536752.1 NC_011206:1414294-1414548 [Acidithiobacillus ferrooxidans ATCC 53993]
MAILTVRNVPDDVHRALRVRAARHGRSTEAEVREILAAAVKPSSRVCMGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LRFD

Download         Length: 255 bp

>AT23073 NC_011206:1414294-1414548 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGGCAATCCTGACTGTAAGAAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCGGCACGGTCGCAG
CACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCTGCGGTCAAACCTTCGAGCCGCGTGTGCATGGGGGAAGCCCTGGCCG
CCATCGGCCGCAAGATCGGTCTGACCAATGAAGATTTCGCCGTTTTCGAGAGTGTGCGCGACAAGACGCCGGCCAAACCG
TTGCGCTTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB7JBN6

Antitoxin

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Source
ID
Structure
AlphaFold DBB7JBN5

References