Detailed information of TA system TA230722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4778463..4778979
• Replicon: chromosome
• Accession: NZ_CP090429
• Organism: Klebsiella pneumoniae strain DY1928

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LYZ32_RS23500
• Protein ID: WP_023317444.1
• Coordinates: 4778463..4778747 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LYZ32_RS23505
• Protein ID: WP_002886901.1
• Coordinates: 4778737..4778979 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYZ32_RS23475 (4773858)	4773858..4774121	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
LYZ32_RS23480 (4774251)	4774251..4774424	+	174	WP_032408826.1	hypothetical protein	-
LYZ32_RS23485 (4774427)	4774427..4775170	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
LYZ32_RS23490 (4775527)	4775527..4777665	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
LYZ32_RS23495 (4777995)	4777995..4778459	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LYZ32_RS23500 (4778463)	4778463..4778747	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LYZ32_RS23505 (4778737)	4778737..4778979	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LYZ32_RS23510 (4779057)	4779057..4780967	-	1911	WP_004152270.1	PRD domain-containing protein	-
LYZ32_RS23515 (4780990)	4780990..4782144	-	1155	WP_002886900.1	lactonase family protein	-
LYZ32_RS23520 (4782211)	4782211..4782951	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T230722 WP_023317444.1 NZ_CP090429:c4778747-4778463 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T230722 NZ_CP125343:c4805017-4804484 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT230722 WP_002886901.1 NZ_CP090429:c4778979-4778737 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT230722 NZ_CP125343:c4805294-4805028 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0