Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2694721..2696309 Replicon chromosome
Accession NZ_CP090429
Organism Klebsiella pneumoniae strain DY1928

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LYZ32_RS13350 Protein ID WP_032436337.1
Coordinates 2694721..2696043 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LYZ32_RS13355 Protein ID WP_002904790.1
Coordinates 2696043..2696309 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYZ32_RS13335 (2689778) 2689778..2692279 + 2502 Protein_2613 fimbrial biogenesis outer membrane usher protein -
LYZ32_RS13340 (2692267) 2692267..2693271 + 1005 WP_032436338.1 fimbrial protein -
LYZ32_RS13345 (2693412) 2693412..2694704 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LYZ32_RS13350 (2694721) 2694721..2696043 - 1323 WP_032436337.1 type II toxin-antitoxin system HipA family toxin Toxin
LYZ32_RS13355 (2696043) 2696043..2696309 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LYZ32_RS13360 (2696696) 2696696..2697022 - 327 WP_032436336.1 hydroxyisourate hydrolase -
LYZ32_RS13365 (2697019) 2697019..2697519 - 501 WP_032436335.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LYZ32_RS13370 (2697497) 2697497..2698876 - 1380 Protein_2620 purine permease -
LYZ32_RS13375 (2699222) 2699222..2700376 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LYZ32_RS13380 (2700357) 2700357..2701280 - 924 WP_032436334.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-103)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49106.39 Da        Isoelectric Point: 7.5617

>T230719 WP_032436337.1 NZ_CP090429:c2696043-2694721 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T230719 NZ_CP125343:2013618-2013720 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT230719 WP_002904790.1 NZ_CP090429:c2696309-2696043 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT230719 NZ_CP125343:c2013727-2013582 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References