Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812576..813233 Replicon chromosome
Accession NZ_CP090429
Organism Klebsiella pneumoniae strain DY1928

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LYZ32_RS04025 Protein ID WP_002916310.1
Coordinates 812823..813233 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LYZ32_RS04020 Protein ID WP_002916312.1
Coordinates 812576..812842 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYZ32_RS03995 (807784) 807784..809217 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LYZ32_RS04000 (809336) 809336..810064 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LYZ32_RS04005 (810114) 810114..810425 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LYZ32_RS04010 (810589) 810589..811248 + 660 WP_002916317.1 hemolysin III family protein -
LYZ32_RS04015 (811347) 811347..812330 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
LYZ32_RS04020 (812576) 812576..812842 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LYZ32_RS04025 (812823) 812823..813233 + 411 WP_002916310.1 protein YgfX Toxin
LYZ32_RS04030 (813240) 813240..813761 - 522 WP_004144730.1 flavodoxin FldB -
LYZ32_RS04035 (813862) 813862..814758 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LYZ32_RS04040 (814781) 814781..815494 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LYZ32_RS04045 (815500) 815500..817233 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T230710 WP_002916310.1 NZ_CP090429:812823-813233 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T230710 NZ_CP125338:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230710 WP_002916312.1 NZ_CP090429:812576-812842 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230710 NZ_CP125338:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References