Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 918633..919207 Replicon chromosome
Accession NZ_CP090428
Organism Pasteurella multocida strain SD001

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag LZP98_RS04330 Protein ID WP_014667974.1
Coordinates 918923..919207 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag LZP98_RS04325 Protein ID WP_014391174.1
Coordinates 918633..918926 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZP98_RS04305 (LZP98_04305) 913798..914889 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
LZP98_RS04310 (LZP98_04310) 915238..917028 + 1791 WP_170347701.1 PTS ascorbate-specific subunit IIBC -
LZP98_RS04315 (LZP98_04315) 917073..917540 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
LZP98_RS04320 (LZP98_04320) 917558..918235 + 678 WP_014667975.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
LZP98_RS04325 (LZP98_04325) 918633..918926 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
LZP98_RS04330 (LZP98_04330) 918923..919207 - 285 WP_014667974.1 addiction module protein Toxin
LZP98_RS04340 (LZP98_04340) 920501..920762 - 262 Protein_829 hypothetical protein -
LZP98_RS04345 (LZP98_04345) 921074..921259 - 186 WP_016534551.1 hypothetical protein -
LZP98_RS04350 (LZP98_04350) 921559..923745 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 920501..920662 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T230707 WP_014667974.1 NZ_CP090428:c919207-918923 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T230707 NZ_CP125336:c31014-30598 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT230707 WP_014391174.1 NZ_CP090428:c918926-918633 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp

>AT230707 NZ_CP125336:c31241-31011 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References