Detailed information of TA system TA230703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 107839..109422
• Replicon: chromosome
• Accession: NZ_CP090418
• Organism: Stenotrophomonas maltophilia strain WGB211

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LYZ64_RS00475
• Protein ID: WP_164090701.1
• Coordinates: 107839..109161 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LYZ64_RS00480
• Protein ID: WP_106466690.1
• Coordinates: 109165..109422 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYZ64_RS00460	103321..104955	-	1635	WP_164090249.1	TldD/PmbA family protein	-
LYZ64_RS00465	104986..106617	-	1632	WP_164090248.1	TldD/PmbA family protein	-
LYZ64_RS00470	107224..107838	+	615	WP_164090702.1	DUF938 domain-containing protein	-
LYZ64_RS00475	107839..109161	-	1323	WP_164090701.1	type II toxin-antitoxin system HipA family toxin	Toxin
LYZ64_RS00480	109165..109422	-	258	WP_106466690.1	helix-turn-helix transcriptional regulator	Antitoxin
LYZ64_RS00485	109580..113266	-	3687	WP_234500131.1	indolepyruvate ferredoxin oxidoreductase family protein	-
LYZ64_RS00490	113435..114070	+	636	WP_106466692.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (152-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48839.60 Da
• Isoelectric Point: 6.8739

>T230703 WP_164090701.1 NZ_CP090418:c109161-107839 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVALWDDVRSGSSRLSYVDSWISSAQSRPLSLSLPLLPKGESHRGNVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGDIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
ADGRFRLTPVYDVLSVHPILGRGPNQLDPQNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPVNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T230703 NZ_CP125334:c5382513-5382130 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 11.8979

>AT230703 WP_106466690.1 NZ_CP090418:c109422-109165 [Stenotrophomonas maltophilia]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVSLQQRSPPETT
PTLEW

Nucleotide

• Length: 258 bp

>AT230703 NZ_CP125334:c5382755-5382513 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA