Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 1231423..1231989 | Replicon | chromosome |
| Accession | NZ_CP090414 | ||
| Organism | Bifidobacterium longum strain T1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0L7BQL3 |
| Locus tag | LZF93_RS05355 | Protein ID | WP_029680114.1 |
| Coordinates | 1231423..1231716 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | I3BGP0 |
| Locus tag | LZF93_RS05360 | Protein ID | WP_007056990.1 |
| Coordinates | 1231720..1231989 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZF93_RS05315 (LZF93_05315) | 1227454..1228080 | - | 627 | WP_234146618.1 | MFS transporter | - |
| LZF93_RS05320 (LZF93_05320) | 1228112..1228225 | - | 114 | WP_019727562.1 | hypothetical protein | - |
| LZF93_RS05325 (LZF93_05325) | 1228394..1228855 | - | 462 | WP_019727563.1 | HipA N-terminal domain-containing protein | - |
| LZF93_RS05330 (LZF93_05330) | 1228879..1229172 | - | 294 | WP_012471870.1 | hypothetical protein | - |
| LZF93_RS05335 (LZF93_05335) | 1229265..1229906 | - | 642 | WP_234146619.1 | moaA protein | - |
| LZF93_RS05340 (LZF93_05340) | 1230120..1230299 | + | 180 | WP_007056286.1 | antitoxin VbhA family protein | - |
| LZF93_RS05345 (LZF93_05345) | 1230296..1230880 | + | 585 | WP_234146620.1 | Fic family protein | - |
| LZF93_RS05350 (LZF93_05350) | 1230947..1231381 | - | 435 | WP_234146621.1 | hypothetical protein | - |
| LZF93_RS05355 (LZF93_05355) | 1231423..1231716 | - | 294 | WP_029680114.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| LZF93_RS05360 (LZF93_05360) | 1231720..1231989 | - | 270 | WP_007056990.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LZF93_RS05365 (LZF93_05365) | 1232174..1232509 | - | 336 | WP_234147297.1 | FtsX-like permease family protein | - |
| LZF93_RS05370 (LZF93_05370) | 1233353..1234021 | - | 669 | Protein_1048 | ABC transporter ATP-binding protein | - |
| LZF93_RS05375 (LZF93_05375) | 1234018..1234798 | - | 781 | Protein_1049 | hypothetical protein | - |
| LZF93_RS05380 (LZF93_05380) | 1234795..1235139 | - | 345 | WP_229025222.1 | hypothetical protein | - |
| LZF93_RS05385 (LZF93_05385) | 1235203..1235817 | + | 615 | WP_234146622.1 | histidine kinase | - |
| LZF93_RS05390 (LZF93_05390) | 1235814..1236137 | - | 324 | WP_234146624.1 | hypothetical protein | - |
| LZF93_RS05395 (LZF93_05395) | 1236551..1236733 | - | 183 | WP_234146625.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1217654..1241988 | 24334 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11160.90 Da Isoelectric Point: 9.7881
>T230701 WP_029680114.1 NZ_CP090414:c1231716-1231423 [Bifidobacterium longum]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK
Download Length: 294 bp
>T230701 NZ_CP125334:c4900732-4900448 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9844.16 Da Isoelectric Point: 4.5742
>AT230701 WP_007056990.1 NZ_CP090414:c1231989-1231720 [Bifidobacterium longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI
Download Length: 270 bp
>AT230701 NZ_CP125334:c4900964-4900722 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L7BQL3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3BGP0 |