Detailed information of TA system TA230700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 915775..916295
• Replicon: chromosome
• Accession: NZ_CP090414
• Organism: Bifidobacterium longum strain T1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I3B070
• Locus tag: LZF93_RS03955
• Protein ID: WP_007053504.1
• Coordinates: 915775..916029 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: I3B069
• Locus tag: LZF93_RS03960
• Protein ID: WP_007051980.1
• Coordinates: 916029..916295 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZF93_RS03930 (LZF93_03930)	911448..913076	-	1629	WP_234147198.1	ATP-binding protein	-
LZF93_RS03935 (LZF93_03935)	913213..913458	-	246	WP_234147199.1	hypothetical protein	-
LZF93_RS03940 (LZF93_03940)	913727..914257	+	531	WP_234147200.1	hypothetical protein	-
LZF93_RS03945 (LZF93_03945)	914254..914634	+	381	WP_007051977.1	hypothetical protein	-
LZF93_RS03950 (LZF93_03950)	914717..915781	+	1065	WP_007051978.1	hypothetical protein	-
LZF93_RS03955 (LZF93_03955)	915775..916029	-	255	WP_007053504.1	Txe/YoeB family addiction module toxin	Toxin
LZF93_RS03960 (LZF93_03960)	916029..916295	-	267	WP_007051980.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LZF93_RS03965 (LZF93_03965)	916480..916860	+	381	WP_007051981.1	hypothetical protein	-
LZF93_RS03970 (LZF93_03970)	916883..917305	+	423	WP_007053503.1	hypothetical protein	-
LZF93_RS03975 (LZF93_03975)	917390..917731	+	342	WP_226746501.1	hypothetical protein	-
LZF93_RS03980 (LZF93_03980)	917934..918251	-	318	WP_007057238.1	HigA family addiction module antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	899117..953566	54449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-76)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9946.38 Da
• Isoelectric Point: 8.4890

>T230700 WP_007053504.1 NZ_CP090414:c916029-915775 [Bifidobacterium longum]
MLLCWTDDAWADYLYWQAQDRRTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Nucleotide

• Length: 255 bp

>T230700 NZ_CP125334:c4797688-4797155 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9922.13 Da
• Isoelectric Point: 4.3407

>AT230700 WP_007051980.1 NZ_CP090414:c916295-916029 [Bifidobacterium longum]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLVEAGA

Nucleotide

• Length: 267 bp

>AT230700 NZ_CP125334:c4797965-4797699 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: I3B070

Antitoxin

• AlphaFold DB: I3B069