Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafQ-relB/YafQ-DinJ |
| Location | 1020983..1021563 | Replicon | chromosome |
| Accession | NZ_CP090409 | ||
| Organism | Lactobacillus gasseri 2016 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | A0A249NKC7 |
| Locus tag | M497_RS04895 | Protein ID | WP_003647258.1 |
| Coordinates | 1021258..1021563 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A249NIV0 |
| Locus tag | M497_RS04890 | Protein ID | WP_021314843.1 |
| Coordinates | 1020983..1021258 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M497_RS04860 (M497_04860) | 1016862..1017752 | - | 891 | WP_003651609.1 | GRP family sugar transporter | - |
| M497_RS04865 (M497_04865) | 1017779..1018174 | - | 396 | WP_003647263.1 | D-ribose pyranase | - |
| M497_RS04870 (M497_04870) | 1018283..1018732 | - | 450 | WP_003647262.1 | ASCH domain-containing protein | - |
| M497_RS04875 (M497_04875) | 1018735..1019499 | - | 765 | Protein_955 | nucleoside phosphorylase | - |
| M497_RS04880 (M497_04880) | 1019626..1020114 | - | 489 | WP_003647261.1 | GNAT family N-acetyltransferase | - |
| M497_RS04885 (M497_04885) | 1020117..1020650 | - | 534 | WP_003647260.1 | GNAT family N-acetyltransferase | - |
| M497_RS04890 (M497_04890) | 1020983..1021258 | + | 276 | WP_021314843.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| M497_RS04895 (M497_04895) | 1021258..1021563 | + | 306 | WP_003647258.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| M497_RS04900 (M497_04900) | 1021726..1022541 | - | 816 | WP_003647256.1 | Fic family protein | - |
| M497_RS04905 (M497_04905) | 1022686..1023474 | - | 789 | WP_003647255.1 | tyrosine-protein phosphatase | - |
| M497_RS09295 | 1023686..1023811 | - | 126 | WP_003652525.1 | hypothetical protein | - |
| M497_RS04910 (M497_04910) | 1023846..1024565 | - | 720 | WP_003647253.1 | hypothetical protein | - |
| M497_RS04915 (M497_04915) | 1024572..1024931 | - | 360 | WP_003647252.1 | DUF6176 family protein | - |
| M497_RS04920 (M497_04920) | 1024924..1025226 | - | 303 | WP_003647251.1 | MazG-like family protein | - |
| M497_RS04925 (M497_04925) | 1025238..1026047 | - | 810 | WP_003647250.1 | DUF2785 domain-containing protein | - |
| M497_RS04930 (M497_04930) | 1026050..1026497 | - | 448 | Protein_967 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11985.87 Da Isoelectric Point: 10.2029
>T230699 WP_003647258.1 NZ_CP090409:1021258-1021563 [Lactobacillus gasseri 2016]
MAQINYTPQFKRDYKKLKRKHYDLNKLKNVIQLLIDEKFKILVDKYDDHQLKGSLRSLRALHVEHNKAGNWILVYKIHSG
NLELLTIDLVSTGSHDHTYRT
MAQINYTPQFKRDYKKLKRKHYDLNKLKNVIQLLIDEKFKILVDKYDDHQLKGSLRSLRALHVEHNKAGNWILVYKIHSG
NLELLTIDLVSTGSHDHTYRT
Download Length: 306 bp
>T230699 NZ_CP125334:4184866-4185084 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10461.79 Da Isoelectric Point: 4.8096
>AT230699 WP_021314843.1 NZ_CP090409:1020983-1021258 [Lactobacillus gasseri 2016]
MTTTVSLRLPEDLKKQATDVFNEYGLDWSSAMRMILTQVVSENAIPVNLHRYSEISPSMKSNIDRSLQEYKAGNYKTTNS
VKELFEELDKD
MTTTVSLRLPEDLKKQATDVFNEYGLDWSSAMRMILTQVVSENAIPVNLHRYSEISPSMKSNIDRSLQEYKAGNYKTTNS
VKELFEELDKD
Download Length: 276 bp
>AT230699 NZ_CP125334:4184465-4184839 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249NKC7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249NIV0 |