Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2057313..2058089 Replicon chromosome
Accession NZ_CP090407
Organism Staphylococcus aureus strain GD4SA159-1

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LZ183_RS09995 Protein ID WP_000031108.1
Coordinates 2057313..2057465 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LZ183_RS10000 Protein ID WP_001251224.1
Coordinates 2057490..2058089 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ183_RS09980 (LZ183_09960) 2053518..2054339 + 822 WP_000669380.1 RluA family pseudouridine synthase -
LZ183_RS09985 (LZ183_09965) 2054794..2056179 - 1386 WP_113587793.1 class II fumarate hydratase -
LZ183_RS09990 (LZ183_09970) 2056375..2056770 - 396 WP_000901018.1 hypothetical protein -
LZ183_RS09995 (LZ183_09975) 2057313..2057465 - 153 WP_000031108.1 SAS053 family protein Toxin
LZ183_RS10000 (LZ183_09980) 2057490..2058089 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LZ183_RS10005 (LZ183_09985) 2058248..2058718 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LZ183_RS10010 (LZ183_09990) 2058723..2059850 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LZ183_RS10015 (LZ183_09995) 2060001..2060723 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
LZ183_RS10020 (LZ183_10000) 2060716..2062173 - 1458 WP_113587791.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T230693 WP_000031108.1 NZ_CP090407:c2057465-2057313 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T230693 NZ_CP125334:322580-322948 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT230693 WP_001251224.1 NZ_CP090407:c2058089-2057490 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT230693 NZ_CP125334:322362-322583 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References