Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1014719..1015195 Replicon chromosome
Accession NZ_CP090407
Organism Staphylococcus aureus strain GD4SA159-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LZ183_RS04980 Protein ID WP_000052076.1
Coordinates 1014719..1014907 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LZ183_RS04985 Protein ID WP_001059690.1
Coordinates 1014935..1015195 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ183_RS04950 (LZ183_04935) 1010239..1010925 + 687 WP_001574556.1 thermonuclease family protein -
LZ183_RS04955 (LZ183_04940) 1011282..1011482 + 201 WP_001059082.1 cold-shock protein -
LZ183_RS04960 (LZ183_04945) 1011979..1012197 - 219 WP_000005881.1 hypothetical protein -
LZ183_RS04965 (LZ183_04950) 1012258..1012542 - 285 WP_001004403.1 hypothetical protein -
LZ183_RS04970 (LZ183_04955) 1012630..1013199 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
LZ183_RS04975 (LZ183_04960) 1013367..1014539 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
LZ183_RS04980 (LZ183_04965) 1014719..1014907 - 189 WP_000052076.1 hypothetical protein Toxin
LZ183_RS04985 (LZ183_04970) 1014935..1015195 - 261 WP_001059690.1 hypothetical protein Antitoxin
LZ183_RS04990 (LZ183_04975) 1015537..1015740 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LZ183_RS04995 (LZ183_04980) 1015737..1015973 - 237 WP_000368687.1 hypothetical protein -
LZ183_RS05000 (LZ183_04985) 1016198..1016779 + 582 WP_001140696.1 histidine phosphatase family protein -
LZ183_RS05005 (LZ183_04990) 1016852..1017469 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
LZ183_RS05010 (LZ183_04995) 1017618..1018112 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
LZ183_RS05015 (LZ183_05000) 1018511..1018933 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
LZ183_RS05020 (LZ183_05005) 1019081..1019797 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1013367..1014539 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T230692 WP_000052076.1 NZ_CP090407:c1014907-1014719 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T230692 NZ_CP125315:c2498401-2498018 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGATCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAATAACGTTGGCAATCACTATAGTCCCACCGTCATTGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGCTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT230692 WP_001059690.1 NZ_CP090407:c1015195-1014935 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT230692 NZ_CP125315:c2498669-2498421 [Lacticaseibacillus rhamnosus]
ATGAAGAAGGAAACGTCAGTAACGGTCGCGCTTGATAGTGCTATCAAAGCGCGTTTGGATGCCTATTGCGAGTTGAATGA
TATGGGTGTTCAGGATGTCATTACTGAAGCAGTGGCGAAGTTTTTGCAGTCACAAGCACCTGAGATCAATCAATTGATTT
CGGGCTATGTGGCAATGGGACAAATCAATACGGAAATTAGCCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References