Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 979099..979624 Replicon chromosome
Accession NC_011206
Organism Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)


Gene name stbE Uniprot ID B7J6U7
Locus tag LFERR_RS05050 Protein ID WP_009564272.1
Coordinates 979343..979624 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7J6U6
Locus tag LFERR_RS05045 Protein ID WP_009564270.1
Coordinates 979099..979353 (+) Length 85 a.a.

Genomic Context

LFERR_RS05010LFERR_RS05015LFERR_RS05020LFERR_RS05025LFERR_RS05030LFERR_RS14445LFERR_RS05040LFERR_RS05045LFERR_RS05050LFERR_RS05065LFERR_RS05005LFERR_RS05060
Location: 975015..975459 (445 bp)
Type: Others
Protein ID: Protein_994
Location: 975628..976296 (669 bp)
Type: Others
Protein ID: WP_009561118.1
Location: 976293..977456 (1164 bp)
Type: Others
Protein ID: WP_012536412.1
Location: 977453..977542 (90 bp)
Type: Others
Protein ID: Protein_997
Location: 977514..977799 (286 bp)
Type: Others
Protein ID: Protein_998
Location: 978030..978365 (336 bp)
Type: Others
Protein ID: WP_012536413.1
Location: 978552..978851 (300 bp)
Type: Others
Protein ID: WP_009564269.1
Location: 979099..979353 (255 bp)
Type: Antitoxin
Protein ID: WP_009564270.1
Location: 979343..979624 (282 bp)
Type: Toxin
Protein ID: WP_009564272.1
Location: 981545..982597 (1053 bp)
Type: Others
Protein ID: WP_012536417.1
Location: 974146..974817 (672 bp)
Type: Others
Protein ID: WP_012536411.1
Location: 980167..981390 (1224 bp)
Type: Others
Protein ID: WP_012536416.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFERR_RS05005974146..974817-672WP_012536411.1LysR family transcriptional regulator-
LFERR_RS05010975015..975459+445Protein_994SDR family oxidoreductase-
LFERR_RS05015975628..976296+669WP_009561118.1cupin domain-containing protein-
LFERR_RS05020976293..977456+1164WP_012536412.1FAD-dependent oxidoreductase-
LFERR_RS05025977453..977542+90Protein_997short-chain dehydrogenase-
LFERR_RS05030977514..977799+286Protein_998hypothetical protein-
LFERR_RS14445978030..978365+336WP_012536413.1shufflon-specific DNA recombinase-
LFERR_RS05040978552..978851+300WP_009564269.1YbjQ family protein-
LFERR_RS05045979099..979353+255WP_009564270.1antitoxinAntitoxin
LFERR_RS05050979343..979624+282WP_009564272.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LFERR_RS05060980167..981390-1224WP_012536416.1class I SAM-dependent rRNA methyltransferase-
LFERR_RS05065981545..982597+1053WP_012536417.1S-methyl-5-thioribose-1-phosphate isomerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10757.61 Da        Isoelectric Point: 10.6855

>T23069 WP_009564272.1 NC_011206:979343-979624 [Acidithiobacillus ferrooxidans ATCC 53993]
MPYELTFHPSALKEWQALDHSVRAPFKKKLAERLVHPRVPSAQLHGHPDRYKIKLRSIGYRLIYQVMETEVQVLVLAVGK
REGSVAYHKAKGR

Download         Length: 282 bp

>T23069 NC_011206:979343-979624 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGCCTTATGAGCTCACTTTCCATCCCTCCGCCCTCAAAGAATGGCAGGCCTTGGACCATAGCGTCCGTGCCCCATTCAA
AAAGAAACTGGCAGAACGCTTAGTGCACCCACGCGTCCCTTCCGCTCAACTGCATGGCCACCCGGATCGCTATAAGATCA
AACTCCGCAGCATAGGCTATCGCTTGATCTACCAAGTGATGGAAACGGAAGTCCAAGTGTTGGTCCTGGCGGTAGGCAAG
CGGGAAGGCTCTGTCGCCTATCACAAGGCCAAAGGACGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8832.16 Da        Isoelectric Point: 4.6615

>AT23069 WP_009564270.1 NC_011206:979099-979353 [Acidithiobacillus ferrooxidans ATCC 53993]
MTHVILADVAASVSELKKNPMGTVAAGEGATVAILNRNEPAFYCVPAATYAALLEHLENLELNALAESRLKDGQTPIKVS
LDAL

Download         Length: 255 bp

>AT23069 NC_011206:979099-979353 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGACCCACGTCATTCTTGCCGATGTTGCTGCCAGTGTTTCCGAACTCAAAAAGAACCCTATGGGAACCGTGGCCGCAGG
AGAAGGGGCTACTGTGGCCATTCTCAACCGCAACGAACCGGCTTTTTACTGTGTCCCAGCCGCTACCTATGCTGCGCTTC
TGGAACATCTGGAAAATTTGGAGCTGAACGCTTTGGCGGAAAGCCGTCTGAAGGATGGCCAAACCCCGATCAAGGTGTCG
CTGGATGCCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB7J6U7

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J6U6

References