Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 392796..393584 | Replicon | chromosome |
| Accession | NZ_CP090407 | ||
| Organism | Staphylococcus aureus strain GD4SA159-1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | LZ183_RS01765 | Protein ID | WP_000525004.1 |
| Coordinates | 392796..393257 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | LZ183_RS01770 | Protein ID | WP_000333630.1 |
| Coordinates | 393270..393584 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ183_RS01740 (LZ183_01735) | 387848..389782 | + | 1935 | Protein_345 | YSIRK domain-containing triacylglycerol lipase Lip2/Geh | - |
| LZ183_RS01745 (LZ183_01740) | 389876..391081 | - | 1206 | WP_031912283.1 | tyrosine-type recombinase/integrase | - |
| LZ183_RS01750 (LZ183_01745) | 391207..391821 | + | 615 | WP_001568848.1 | phage protein | - |
| LZ183_RS01755 (LZ183_01750) | 391818..391964 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| LZ183_RS01760 (LZ183_01755) | 392194..392778 | - | 585 | WP_000825948.1 | hypothetical protein | - |
| LZ183_RS01765 (LZ183_01760) | 392796..393257 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| LZ183_RS01770 (LZ183_01765) | 393270..393584 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LZ183_RS01775 (LZ183_01770) | 393736..393972 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| LZ183_RS01780 (LZ183_01775) | 393986..394762 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| LZ183_RS01785 (LZ183_01780) | 394791..394934 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| LZ183_RS01790 (LZ183_01785) | 394924..395133 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| LZ183_RS01795 (LZ183_01790) | 395189..395338 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| LZ183_RS01800 (LZ183_01795) | 395379..395591 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| LZ183_RS01805 (LZ183_01800) | 395661..395858 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| LZ183_RS01810 (LZ183_01805) | 395845..396225 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| LZ183_RS01815 (LZ183_01810) | 396292..396537 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| LZ183_RS01820 (LZ183_01815) | 396506..396871 | - | 366 | WP_001128432.1 | hypothetical protein | - |
| LZ183_RS01825 (LZ183_01820) | 396926..397141 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| LZ183_RS01830 (LZ183_01825) | 397166..397429 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| LZ183_RS01835 (LZ183_01830) | 397442..397603 | + | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| LZ183_RS01840 (LZ183_01835) | 397682..398005 | + | 324 | WP_000175000.1 | hypothetical protein | - |
| LZ183_RS01845 (LZ183_01840) | 398020..398382 | + | 363 | WP_000985986.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | dfrG | - | 389876..436563 | 46687 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T230688 WP_000525004.1 NZ_CP090407:c393257-392796 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T230688 NZ_CP125314:c37895-37746 [Citrobacter freundii]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT230688 WP_000333630.1 NZ_CP090407:c393584-393270 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT230688 NZ_CP125314:37940-37999 [Citrobacter freundii]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |