Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 45695..46188 | Replicon | plasmid pPIB-4 |
| Accession | NZ_CP090406 | ||
| Organism | Shigella sp. PIB | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9Y9W8 |
| Locus tag | LXH19_RS24115 | Protein ID | WP_001230709.1 |
| Coordinates | 45934..46188 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | U9Y4R8 |
| Locus tag | LXH19_RS24110 | Protein ID | WP_000151456.1 |
| Coordinates | 45695..45937 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXH19_RS24070 (LXH19_24065) | 40960..41550 | + | 591 | WP_124827468.1 | transglycosylase SLT domain-containing protein | - |
| LXH19_RS24075 (LXH19_24070) | 41847..42668 | - | 822 | WP_001234372.1 | DUF932 domain-containing protein | - |
| LXH19_RS24080 (LXH19_24075) | 42779..42928 | - | 150 | WP_233337085.1 | hypothetical protein | - |
| LXH19_RS24085 (LXH19_24080) | 43200..43502 | - | 303 | WP_000379301.1 | hypothetical protein | - |
| LXH19_RS24090 (LXH19_24085) | 43578..43811 | - | 234 | WP_000093745.1 | hypothetical protein | - |
| LXH19_RS24095 (LXH19_24090) | 44239..44526 | - | 288 | WP_000606467.1 | hypothetical protein | - |
| LXH19_RS24100 (LXH19_24095) | 44831..45124 | - | 294 | WP_000673431.1 | hypothetical protein | - |
| LXH19_RS24105 (LXH19_24100) | 45256..45474 | - | 219 | WP_154101533.1 | hypothetical protein | - |
| LXH19_RS24110 (LXH19_24105) | 45695..45937 | - | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
| LXH19_RS24115 (LXH19_24110) | 45934..46188 | - | 255 | WP_001230709.1 | hypothetical protein | Toxin |
| LXH19_RS24120 (LXH19_24115) | 46185..46727 | - | 543 | WP_001083904.1 | hypothetical protein | - |
| LXH19_RS24125 (LXH19_24120) | 46831..47346 | - | 516 | WP_001025393.1 | J domain-containing protein | - |
| LXH19_RS24130 (LXH19_24125) | 48181..48531 | - | 351 | WP_000127482.1 | addiction module antitoxin | - |
| LXH19_RS24135 (LXH19_24130) | 48518..48862 | - | 345 | WP_001146936.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LXH19_RS24140 (LXH19_24135) | 49216..49539 | - | 324 | WP_000432873.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..50465 | 50465 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T230687 WP_001230709.1 NZ_CP090406:c46188-45934 [Shigella sp. PIB]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T230687 NZ_CP125312:c70304-69993 [Citrobacter freundii]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAGCGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAGCGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT230687 WP_000151456.1 NZ_CP090406:c45937-45695 [Shigella sp. PIB]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT230687 NZ_CP125312:c69996-69577 [Citrobacter freundii]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACTTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCGGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCATTAACACTGGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCAA
GCTCATTCATGGACGCGTAA
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACTTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCGGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCATTAACACTGGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCAA
GCTCATTCATGGACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9H8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9GNF5 |