Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 46310..46902 Replicon plasmid pPIB-3
Accession NZ_CP090405
Organism Shigella sp. PIB

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag LXH19_RS23725 Protein ID WP_000513532.1
Coordinates 46310..46558 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag LXH19_RS23730 Protein ID WP_000681609.1
Coordinates 46555..46902 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS23685 (LXH19_23680) 41316..41981 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
LXH19_RS23690 (LXH19_23685) 42571..42900 + 330 WP_001542022.1 hypothetical protein -
LXH19_RS23695 (LXH19_23690) 43301..43816 + 516 WP_001025393.1 J domain-containing protein -
LXH19_RS23700 (LXH19_23695) 43920..44462 + 543 WP_001083904.1 hypothetical protein -
LXH19_RS23705 (LXH19_23700) 44459..44713 + 255 WP_001230709.1 hypothetical protein -
LXH19_RS23710 (LXH19_23705) 44710..44952 + 243 WP_000151456.1 hypothetical protein -
LXH19_RS23715 (LXH19_23710) 45173..45391 + 219 WP_154101533.1 hypothetical protein -
LXH19_RS23720 (LXH19_23715) 45523..45816 + 294 WP_000673428.1 hypothetical protein -
LXH19_RS23725 (LXH19_23720) 46310..46558 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
LXH19_RS23730 (LXH19_23725) 46555..46902 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LXH19_RS23735 (LXH19_23730) 46990..47433 - 444 WP_023223351.1 hypothetical protein -
LXH19_RS23740 (LXH19_23735) 47674..47973 + 300 WP_034169410.1 type II toxin-antitoxin system HicB family antitoxin -
LXH19_RS23745 (LXH19_23740) 48233..48559 - 327 WP_000206697.1 hypothetical protein -
LXH19_RS23750 (LXH19_23745) 48561..48899 - 339 WP_029797038.1 hypothetical protein -
LXH19_RS23755 (LXH19_23750) 48879..49001 - 123 Protein_67 hypothetical protein -
LXH19_RS23760 (LXH19_23755) 49021..49728 - 708 WP_000108794.1 hypothetical protein -
LXH19_RS23765 (LXH19_23760) 49730..50482 - 753 WP_000797966.1 conjugal transfer protein TraL -
LXH19_RS23770 (LXH19_23765) 50500..50901 - 402 WP_021575837.1 hypothetical protein -
LXH19_RS23775 (LXH19_23770) 51270..51611 + 342 WP_000730722.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..63625 63625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9378.03 Da        Isoelectric Point: 10.4800

>T230686 WP_000513532.1 NZ_CP090405:46310-46558 [Shigella sp. PIB]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL

Download         Length: 249 bp

>T230686 NZ_CP125311:45154-45657 [Citrobacter freundii]
ATGTTTTCAGCACAAGCCGTATACGATTTTTCGGGCTTCGACTGCGGCGAACCATCTCTGAATGATTTCCTGCAAAACCG
CCTGGTACAGCAACACAACGGGCGTATATTACGTGGCTACCTGCTTCTTACCAAAGATCCGGTGCCGAAAGTTAAGGGGT
TTTACACGCTATCCGGGAGCTGTTTTGCAAGACAGACGCTACCATCGAACACCCAGAAGCGGAAAATCCCCTACGCAGAT
GCACCCAGCGTTACGCTTGGCCGTCTGGCAATAGATATCAGCCTACAGAAACAAGGCTACGGGGAGGTTCTCGTAACGCA
CGCGCTGAAGGTTGTTTATCAGGCTTCTCGCGCAGTAGGCATATACGCTTTGTTTGTGGATGCACTAAACCAAAGCGCAA
TGCAGTTCTATCAGAAGTTTGGATTCATCCCTTTGACGGGGGCGAATGCCAACTCACTTTTCTACCCCACGAAAAGCATT
GAAGAGCTGTTTGAAACAGAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13206.97 Da        Isoelectric Point: 4.8313

>AT230686 WP_000681609.1 NZ_CP090405:46555-46902 [Shigella sp. PIB]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA

Download         Length: 348 bp

>AT230686 NZ_CP125311:44860-45129 [Citrobacter freundii]
ATGTCAGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACGATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGCCGCT
TGATTCTCAGTGAAGAGTCCTGGAATCTGGTAATGGATGCCATCAGTAACCCGCCTGCACCGAACGATAGGCTGAAACGA
GCTGCCAAACGTCTACAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References