Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 26360..26882 | Replicon | plasmid pPIB-3 |
| Accession | NZ_CP090405 | ||
| Organism | Shigella sp. PIB | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | LXH19_RS23565 | Protein ID | WP_000638823.1 |
| Coordinates | 26360..26641 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | LXH19_RS23570 | Protein ID | WP_000121741.1 |
| Coordinates | 26631..26882 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXH19_RS23530 (LXH19_23525) | 22509..22829 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| LXH19_RS23535 (LXH19_23530) | 22900..23190 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| LXH19_RS23540 (LXH19_23535) | 23190..23774 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| LXH19_RS23545 (LXH19_23540) | 23795..24193 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| LXH19_RS23550 (LXH19_23545) | 24312..24749 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| LXH19_RS23555 (LXH19_23550) | 24755..25990 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| LXH19_RS23560 (LXH19_23555) | 25993..26292 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| LXH19_RS23565 (LXH19_23560) | 26360..26641 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LXH19_RS23570 (LXH19_23565) | 26631..26882 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| LXH19_RS23575 (LXH19_23570) | 26982..27617 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| LXH19_RS23580 (LXH19_23575) | 27665..28456 | + | 792 | WP_023154636.1 | DUF5710 domain-containing protein | - |
| LXH19_RS23585 (LXH19_23580) | 28711..28935 | - | 225 | WP_000713561.1 | EexN family lipoprotein | - |
| LXH19_RS23590 (LXH19_23585) | 28944..29588 | - | 645 | WP_001310442.1 | type IV secretion system protein | - |
| LXH19_RS23595 (LXH19_23590) | 29594..30589 | - | 996 | WP_001028541.1 | type IV secretion system protein | - |
| LXH19_RS23600 (LXH19_23595) | 30593..30850 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| LXH19_RS23605 (LXH19_23600) | 30847..31149 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| LXH19_RS23610 (LXH19_23605) | 31420..31632 | - | 213 | WP_039022940.1 | hypothetical protein | - |
| LXH19_RS23615 (LXH19_23610) | 31643..31813 | - | 171 | WP_000550720.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63625 | 63625 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T230684 WP_000638823.1 NZ_CP090405:c26641-26360 [Shigella sp. PIB]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T230684 NZ_CP125310:c4948844-4948569 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT230684 WP_000121741.1 NZ_CP090405:c26882-26631 [Shigella sp. PIB]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT230684 NZ_CP125310:c4948572-4948213 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|