Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 597067..597707 Replicon chromosome
Accession NC_011206
Organism Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LFERR_RS03155 Protein ID WP_009567232.1
Coordinates 597297..597707 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID B7J4M0
Locus tag LFERR_RS03150 Protein ID WP_009567231.1
Coordinates 597067..597297 (+) Length 77 a.a.

Genomic Context

LFERR_RS03135LFERR_RS03140LFERR_RS03145LFERR_RS03150LFERR_RS03155LFERR_RS03160LFERR_RS03165LFERR_RS03170LFERR_RS03175
Location: 592945..594075 (1131 bp)
Type: Others
Protein ID: WP_012536159.1
Location: 594075..595040 (966 bp)
Type: Others
Protein ID: WP_009567244.1
Location: 595041..596858 (1818 bp)
Type: Others
Protein ID: WP_012536160.1
Location: 597067..597297 (231 bp)
Type: Antitoxin
Protein ID: WP_009567231.1
Location: 597297..597707 (411 bp)
Type: Toxin
Protein ID: WP_009567232.1
Location: 597840..598938 (1099 bp)
Type: Others
Protein ID: WP_012606567.1
Location: 598975..600465 (1491 bp)
Type: Others
Protein ID: WP_009568984.1
Location: 600462..601706 (1245 bp)
Type: Others
Protein ID: WP_012536161.1
Location: 601699..602394 (696 bp)
Type: Others
Protein ID: WP_009566877.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFERR_RS03135592945..594075+1131WP_012536159.1threonine synthase-
LFERR_RS03140594075..595040+966WP_009567244.1hypothetical protein-
LFERR_RS03145595041..596858+1818WP_012536160.1single-stranded DNA exonuclease-
LFERR_RS03150597067..597297+231WP_009567231.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
LFERR_RS03155597297..597707+411WP_009567232.1type II toxin-antitoxin system VapC family toxinToxin
LFERR_RS03160597840..598938+1099WP_012606567.1peptide chain release factor 2-
LFERR_RS03165598975..600465+1491WP_009568984.1lysine--tRNA ligase-
LFERR_RS03170600462..601706+1245WP_012536161.1lipoprotein-releasing ABC transporter permease subunit-
LFERR_RS03175601699..602394+696WP_009566877.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15278.46 Da        Isoelectric Point: 7.3848

>T23068 WP_009567232.1 NC_011206:597297-597707 [Acidithiobacillus ferrooxidans ATCC 53993]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Download         Length: 411 bp

>T23068 NC_011206:597297-597707 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGACCTTGCGTTATCTGCTGGATACCAATATCTGCATTTATATTGCCAAACACCATCCGCCCGCCGTGCGGGAGCGTTT
TGTACAACATGGTGCCGATGATCTGGCGATGTCGGTAATCACCTTGGGTGAATTGTGTTGGGGTGCGGAAAAAAGTCAGG
CGCGTGACAAAGCGTTGGCCAGCATACAGCGCCTGCAAGAACGTATTCAGGTGGCCCCCCTCACCCCTCAGGTCGGCATC
CACTATGGCCAGATCCGCGCGGCTCTGGAAAGCGGCGGGCGGCCCATTGGCAATAATGATCTGTGGATCGCCGCACACGC
CCGCGCCGAAGGCTGGATCGTAGTTACCAACAATGAACGAGAGTTCCGACGGGTGGAAGGATTGCAAGTGGAAAACTGGG
TAACGGCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.76 Da        Isoelectric Point: 4.4217

>AT23068 WP_009567231.1 NC_011206:597067-597297 [Acidithiobacillus ferrooxidans ATCC 53993]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Download         Length: 231 bp

>AT23068 NC_011206:597067-597297 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGGCCATCGCACGCATCTTCCAATCAGGCAACAGTCAGGCCGTACGGTTGCCCAAAGAATTCCGCTTTGAGGTGGATCA
GGTGGAAATCTTCCGCCGCGGGAATGAGATTATTCTGCGGGAGCATCCAGTGGATGGTACAGGCGTTTTTGATGCCCTGG
CCGACCTTCCCGAAGACTTCATGTCCGACGGACGCCAGGATATTCCACCCCAGGCAAGGGAAAACTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J4M0

References