Detailed information of TA system TA023067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 251433..251917
• Replicon: chromosome
• Accession: NC_011206
• Organism: Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LFERR_RS01285
• Protein ID: WP_012535934.1
• Coordinates: 251621..251917 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LFERR_RS01280
• Protein ID: WP_012535933.1
• Coordinates: 251433..251621 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFERR_RS01265	247688..247990	+	303	WP_012535930.1	hypothetical protein	-
LFERR_RS01270	247987..248664	+	678	WP_012535931.1	lytic transglycosylase domain-containing protein	-
LFERR_RS01275	248675..251104	+	2430	WP_012535932.1	type IV secretory system conjugative DNA transfer family protein	-
LFERR_RS01280	251433..251621	+	189	WP_012535933.1	hypothetical protein	Antitoxin
LFERR_RS01285	251621..251917	+	297	WP_012535934.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LFERR_RS01290	253330..254967	-	1638	WP_012535935.1	IS66-like element ISAfe4 family transposase	-
LFERR_RS01295	255017..255364	-	348	WP_012535936.1	IS66 family insertion sequence element accessory protein TnpB	-
LFERR_RS01300	255355..255687	-	333	WP_012535937.1	IS66 family insertion sequence hypothetical protein	-
LFERR_RS15215	256223..256675	+	453	WP_155115427.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11357.08 Da
• Isoelectric Point: 5.0744

>T23067 WP_012535934.1 NC_011206:251621-251917 [Acidithiobacillus ferrooxidans ATCC 53993]
MLPIFWLESADADLATIIDYIGQYDVSAAERLWERLRVCVLPLSEHPYLYRISDRVPGLREIVAHPNYIVLYRVTATCIE
VVNVVHARREFPVSTQNE

Nucleotide

• Length: 297 bp

>T23067 NC_011206:251621-251917 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGCTACCTATCTTCTGGCTTGAGTCGGCCGACGCCGATCTAGCCACTATCATAGACTACATCGGTCAGTACGATGTGAG
TGCAGCCGAACGCCTGTGGGAACGCCTGCGCGTCTGTGTGTTGCCACTGTCAGAGCACCCCTACCTGTACCGCATCAGCG
ATCGCGTGCCAGGCTTGCGTGAGATCGTCGCGCACCCAAACTACATCGTGCTCTATCGTGTCACAGCCACCTGCATTGAG
GTGGTGAACGTGGTGCATGCCCGCCGTGAGTTCCCGGTTTCCACCCAAAATGAGTAG

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7000.90 Da
• Isoelectric Point: 5.0203

>AT23067 WP_012535933.1 NC_011206:251433-251621 [Acidithiobacillus ferrooxidans ATCC 53993]
MNAVLPSIISEFETAEQEASYTAWLQAKTAASMADPRPGIPHDEIERRMAERLTRLKQREAS

Nucleotide

• Length: 189 bp

>AT23067 NC_011206:251433-251621 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGAATGCCGTTTTACCTTCCATCATTTCCGAGTTTGAGACCGCCGAGCAGGAGGCCAGCTACACGGCCTGGCTGCAGGC
CAAGACGGCCGCTAGCATGGCCGACCCGCGCCCGGGCATCCCCCACGATGAGATTGAGCGACGCATGGCCGAGCGACTAA
CACGGCTCAAACAGCGCGAAGCGTCCTGA