Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2450817..2451455 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LXH19_RS11700 Protein ID WP_000813794.1
Coordinates 2451279..2451455 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LXH19_RS11695 Protein ID WP_001270286.1
Coordinates 2450817..2451233 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS11675 (2445969) 2445969..2446910 - 942 WP_024216494.1 ABC transporter permease -
LXH19_RS11680 (2446911) 2446911..2447924 - 1014 WP_024042137.1 ABC transporter ATP-binding protein -
LXH19_RS11685 (2447942) 2447942..2449087 - 1146 WP_024042138.1 ABC transporter substrate-binding protein -
LXH19_RS11690 (2449332) 2449332..2450738 - 1407 WP_252321936.1 PLP-dependent aminotransferase family protein -
LXH19_RS11695 (2450817) 2450817..2451233 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LXH19_RS11700 (2451279) 2451279..2451455 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LXH19_RS11705 (2451677) 2451677..2451907 + 231 WP_000494244.1 YncJ family protein -
LXH19_RS11710 (2451999) 2451999..2453960 - 1962 WP_206312624.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LXH19_RS11715 (2454033) 2454033..2454569 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
LXH19_RS11720 (2454661) 2454661..2455833 + 1173 WP_042097662.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T230667 WP_000813794.1 NZ_CP090402:c2451455-2451279 [Shigella sp. PIB]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T230667 NZ_CP125292:2831481-2831831 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT230667 WP_001270286.1 NZ_CP090402:c2451233-2450817 [Shigella sp. PIB]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT230667 NZ_CP125292:2831195-2831476 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References