Detailed information of TA system TA023066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 218478..219515
• Replicon: chromosome
• Accession: NC_011206
• Organism: Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: LFERR_RS01125
• Protein ID: WP_012535903.1
• Coordinates: 218478..219050 (-)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A7T4WBP9
• Locus tag: LFERR_RS01130
• Protein ID: WP_012535904.1
• Coordinates: 219051..219515 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFERR_RS01100	213578..214765	-	1188	WP_012535897.1	restriction endonuclease subunit S	-
LFERR_RS01105	214762..216216	-	1455	WP_012535898.1	type I restriction-modification system subunit M	-
LFERR_RS01110	216318..216692	-	375	WP_012535899.1	type II toxin-antitoxin system VapC family toxin	-
LFERR_RS14735	216689..216886	-	198	WP_012535900.1	type II toxin-antitoxin system VapB family antitoxin	-
LFERR_RS01120	217862..218302	+	441	WP_012535902.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
LFERR_RS01125	218478..219050	-	573	WP_012535903.1	PIN domain-containing protein	Toxin
LFERR_RS01130	219051..219515	-	465	WP_012535904.1	helix-turn-helix domain-containing protein	Antitoxin
LFERR_RS14740	219512..219796	-	285	WP_080515396.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	187366..219515	32149

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (83-130)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21676.90 Da
• Isoelectric Point: 6.6944

>T23066 WP_012535903.1 NC_011206:c219050-218478 [Acidithiobacillus ferrooxidans ATCC 53993]
MSSNFIVIYDACVLYPAPLRDLLMRLALTDLYRARWTDMIHDEWTRNVLKQRPDLKAEDLERTRSLMNAHVRDSLVTGFG
HLIPSVELPDADDRHVVAAAIHGGASLIVTFNLKDFPPERLKPYNLTAQHPDDFIFDLLDLHAARVCEAAANHRRSLKNP
PKTVDEYLDTLLKQGLTQTVGQLREWKVAI

Nucleotide

• Length: 573 bp

>T23066 NC_011206:c219050-218478 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGAGTTCGAACTTCATCGTCATCTACGACGCGTGCGTGCTCTACCCGGCACCGTTGCGCGACCTGCTGATGCGCCTGGC
GCTGACCGATCTGTACCGGGCGCGTTGGACGGACATGATCCACGACGAGTGGACGCGTAACGTTCTGAAGCAGCGGCCAG
ACCTGAAGGCCGAAGACCTGGAGCGGACGCGGTCGCTGATGAACGCCCACGTCCGCGACAGCCTGGTCACCGGCTTCGGG
CATCTGATCCCGTCCGTCGAGTTGCCAGACGCCGATGACCGGCATGTAGTTGCCGCCGCCATTCACGGCGGCGCCAGCCT
GATCGTGACGTTCAACCTGAAGGATTTCCCGCCGGAACGGCTCAAACCCTACAACCTGACCGCCCAGCATCCAGACGACT
TCATCTTCGACCTACTGGATCTGCACGCAGCCCGCGTTTGCGAGGCGGCGGCCAACCATCGACGATCGCTGAAGAACCCG
CCCAAGACGGTTGACGAGTACCTGGACACGCTGCTCAAGCAGGGACTGACACAGACCGTCGGCCAGTTGCGGGAGTGGAA
GGTAGCGATCTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16999.34 Da
• Isoelectric Point: 6.0003

>AT23066 WP_012535904.1 NC_011206:c219515-219051 [Acidithiobacillus ferrooxidans ATCC 53993]
MTTLSPTHSLPTAEEVAIARESGRALSAFLQTRAETQQIEIFNDKGASHSVRVPVSALRLLVDVLTEIGEGNAVSIIPIH
AELTTQDAADVLNVSRPFLVQLLERGEIPFHKIGTHRRVRYQDVIAYKERIDAERSKALDALAEQAQALKMGYE

Nucleotide

• Length: 465 bp

>AT23066 NC_011206:c219515-219051 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGACCACACTCTCTCCCACCCATTCGTTGCCTACGGCCGAAGAAGTTGCCATCGCCCGCGAGAGCGGCCGGGCACTGTC
CGCCTTCCTTCAGACCCGCGCGGAAACCCAGCAGATCGAGATATTCAACGACAAGGGCGCGTCTCATTCGGTCCGCGTCC
CGGTGTCGGCGCTGCGCCTTCTCGTGGACGTACTGACCGAAATCGGTGAGGGCAACGCGGTCAGTATCATCCCGATCCAC
GCCGAACTGACAACGCAAGACGCAGCGGACGTACTCAATGTCTCGCGACCGTTCCTCGTCCAGTTGCTGGAGCGCGGCGA
GATCCCGTTCCACAAGATCGGTACTCACCGTCGTGTCCGCTACCAGGACGTGATCGCGTACAAGGAGCGGATCGACGCTG
AGCGCAGCAAGGCCCTTGATGCACTGGCCGAGCAAGCCCAGGCGCTCAAGATGGGGTACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7T4WBP9