Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 218478..219515 Replicon chromosome
Accession NC_011206
Organism Acidithiobacillus ferrooxidans ATCC 53993

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LFERR_RS01125 Protein ID WP_012535903.1
Coordinates 218478..219050 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A7T4WBP9
Locus tag LFERR_RS01130 Protein ID WP_012535904.1
Coordinates 219051..219515 (-) Length 155 a.a.

Genomic Context

LFERR_RS01120LFERR_RS01100LFERR_RS01105LFERR_RS01110LFERR_RS14735LFERR_RS01125LFERR_RS01130LFERR_RS14740
Location: 217862..218302 (441 bp)
Type: Others
Protein ID: WP_012535902.1
Location: 213578..214765 (1188 bp)
Type: Others
Protein ID: WP_012535897.1
Location: 214762..216216 (1455 bp)
Type: Others
Protein ID: WP_012535898.1
Location: 216318..216692 (375 bp)
Type: Others
Protein ID: WP_012535899.1
Location: 216689..216886 (198 bp)
Type: Others
Protein ID: WP_012535900.1
Location: 218478..219050 (573 bp)
Type: Toxin
Protein ID: WP_012535903.1
Location: 219051..219515 (465 bp)
Type: Antitoxin
Protein ID: WP_012535904.1
Location: 219512..219796 (285 bp)
Type: Others
Protein ID: WP_080515396.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LFERR_RS01100213578..214765-1188WP_012535897.1restriction endonuclease subunit S-
LFERR_RS01105214762..216216-1455WP_012535898.1type I restriction-modification system subunit M-
LFERR_RS01110216318..216692-375WP_012535899.1type II toxin-antitoxin system VapC family toxin-
LFERR_RS14735216689..216886-198WP_012535900.1type II toxin-antitoxin system VapB family antitoxin-
LFERR_RS01120217862..218302+441WP_012535902.11-acyl-sn-glycerol-3-phosphate acyltransferase-
LFERR_RS01125218478..219050-573WP_012535903.1PIN domain-containing proteinToxin
LFERR_RS01130219051..219515-465WP_012535904.1helix-turn-helix domain-containing proteinAntitoxin
LFERR_RS14740219512..219796-285WP_080515396.1TIR domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--187366..21951532149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(83-130)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21676.90 Da        Isoelectric Point: 6.6944

>T23066 WP_012535903.1 NC_011206:c219050-218478 [Acidithiobacillus ferrooxidans ATCC 53993]
MSSNFIVIYDACVLYPAPLRDLLMRLALTDLYRARWTDMIHDEWTRNVLKQRPDLKAEDLERTRSLMNAHVRDSLVTGFG
HLIPSVELPDADDRHVVAAAIHGGASLIVTFNLKDFPPERLKPYNLTAQHPDDFIFDLLDLHAARVCEAAANHRRSLKNP
PKTVDEYLDTLLKQGLTQTVGQLREWKVAI

Download         Length: 573 bp

>T23066 NC_011206:c219050-218478 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGAGTTCGAACTTCATCGTCATCTACGACGCGTGCGTGCTCTACCCGGCACCGTTGCGCGACCTGCTGATGCGCCTGGC
GCTGACCGATCTGTACCGGGCGCGTTGGACGGACATGATCCACGACGAGTGGACGCGTAACGTTCTGAAGCAGCGGCCAG
ACCTGAAGGCCGAAGACCTGGAGCGGACGCGGTCGCTGATGAACGCCCACGTCCGCGACAGCCTGGTCACCGGCTTCGGG
CATCTGATCCCGTCCGTCGAGTTGCCAGACGCCGATGACCGGCATGTAGTTGCCGCCGCCATTCACGGCGGCGCCAGCCT
GATCGTGACGTTCAACCTGAAGGATTTCCCGCCGGAACGGCTCAAACCCTACAACCTGACCGCCCAGCATCCAGACGACT
TCATCTTCGACCTACTGGATCTGCACGCAGCCCGCGTTTGCGAGGCGGCGGCCAACCATCGACGATCGCTGAAGAACCCG
CCCAAGACGGTTGACGAGTACCTGGACACGCTGCTCAAGCAGGGACTGACACAGACCGTCGGCCAGTTGCGGGAGTGGAA
GGTAGCGATCTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16999.34 Da        Isoelectric Point: 6.0003

>AT23066 WP_012535904.1 NC_011206:c219515-219051 [Acidithiobacillus ferrooxidans ATCC 53993]
MTTLSPTHSLPTAEEVAIARESGRALSAFLQTRAETQQIEIFNDKGASHSVRVPVSALRLLVDVLTEIGEGNAVSIIPIH
AELTTQDAADVLNVSRPFLVQLLERGEIPFHKIGTHRRVRYQDVIAYKERIDAERSKALDALAEQAQALKMGYE

Download         Length: 465 bp

>AT23066 NC_011206:c219515-219051 [Acidithiobacillus ferrooxidans ATCC 53993]
ATGACCACACTCTCTCCCACCCATTCGTTGCCTACGGCCGAAGAAGTTGCCATCGCCCGCGAGAGCGGCCGGGCACTGTC
CGCCTTCCTTCAGACCCGCGCGGAAACCCAGCAGATCGAGATATTCAACGACAAGGGCGCGTCTCATTCGGTCCGCGTCC
CGGTGTCGGCGCTGCGCCTTCTCGTGGACGTACTGACCGAAATCGGTGAGGGCAACGCGGTCAGTATCATCCCGATCCAC
GCCGAACTGACAACGCAAGACGCAGCGGACGTACTCAATGTCTCGCGACCGTTCCTCGTCCAGTTGCTGGAGCGCGGCGA
GATCCCGTTCCACAAGATCGGTACTCACCGTCGTGTCCGCTACCAGGACGTGATCGCGTACAAGGAGCGGATCGACGCTG
AGCGCAGCAAGGCCCTTGATGCACTGGCCGAGCAAGCCCAGGCGCTCAAGATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7T4WBP9

References