Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 296215..296846 Replicon chromosome
Accession NZ_CP090402
Organism Shigella sp. PIB

Toxin (Protein)


Gene name hicA Uniprot ID A0A210B5N4
Locus tag LXH19_RS01295 Protein ID WP_033560611.1
Coordinates 296215..296466 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A210B5M4
Locus tag LXH19_RS01300 Protein ID WP_024044889.1
Coordinates 296487..296846 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH19_RS01280 (291219) 291219..292286 + 1068 WP_024043585.1 HlyD family efflux transporter periplasmic adaptor subunit -
LXH19_RS01285 (292283) 292283..295018 + 2736 WP_024216288.1 ribosome-associated ATPase/putative transporter RbbA -
LXH19_RS01290 (295018) 295018..296142 + 1125 WP_001318088.1 ABC transporter permease -
LXH19_RS01295 (296215) 296215..296466 + 252 WP_033560611.1 type II toxin-antitoxin system HicA family toxin Toxin
LXH19_RS01300 (296487) 296487..296846 + 360 WP_024044889.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LXH19_RS01305 (296965) 296965..297366 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LXH19_RS01310 (297372) 297372..298178 - 807 WP_000173688.1 nickel import ATP-binding protein NikE -
LXH19_RS01315 (298175) 298175..298939 - 765 WP_001136200.1 nickel import ATP-binding protein NikD -
LXH19_RS01320 (298939) 298939..299772 - 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
LXH19_RS01325 (299769) 299769..300713 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.84 Da        Isoelectric Point: 10.4909

>T230653 WP_033560611.1 NZ_CP090402:296215-296466 [Shigella sp. PIB]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDW

Download         Length: 252 bp

>T230653 NZ_CP125283:c1237209-1236463 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATAAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13370.23 Da        Isoelectric Point: 5.1797

>AT230653 WP_024044889.1 NZ_CP090402:296487-296846 [Shigella sp. PIB]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYAHTEKIKT
FTLRYPESLSERLTNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT230653 NZ_CP125283:c1236462-1236292 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A210B5N4

Antitoxin

Source ID Structure
AlphaFold DB A0A210B5M4

References