Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 2371326..2373048 | Replicon | chromosome |
| Accession | NZ_CP090399 | ||
| Organism | Vibrio cholerae strain PanChol | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | D0FZT9 |
| Locus tag | LZM82_RS10710 | Protein ID | WP_000356587.1 |
| Coordinates | 2371326..2372264 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A1U9VYW4 |
| Locus tag | LZM82_RS10715 | Protein ID | WP_000095578.1 |
| Coordinates | 2372257..2373048 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZM82_RS10690 (LZM82_10690) | 2367267..2367779 | - | 513 | WP_001166558.1 | S26 family signal peptidase | - |
| LZM82_RS10695 (LZM82_10695) | 2367763..2368110 | - | 348 | WP_001044650.1 | hypothetical protein | - |
| LZM82_RS10700 (LZM82_10700) | 2368103..2370502 | - | 2400 | WP_000648042.1 | type IV secretion system protein TraC | - |
| LZM82_RS10705 (LZM82_10705) | 2370502..2371194 | - | 693 | WP_001228926.1 | DsbC family protein | - |
| LZM82_RS10710 (LZM82_10710) | 2371326..2372264 | - | 939 | WP_000356587.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LZM82_RS10715 (LZM82_10715) | 2372257..2373048 | - | 792 | WP_000095578.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LZM82_RS10720 (LZM82_10720) | 2373269..2373655 | - | 387 | WP_000180223.1 | TraA family conjugative transfer protein | - |
| LZM82_RS10725 (LZM82_10725) | 2373652..2374224 | - | 573 | WP_001944091.1 | type IV conjugative transfer system lipoprotein TraV | - |
| LZM82_RS10730 (LZM82_10730) | 2374299..2375588 | - | 1290 | WP_000647305.1 | TraB/VirB10 family protein | - |
| LZM82_RS10735 (LZM82_10735) | 2375591..2376487 | - | 897 | WP_001911237.1 | type-F conjugative transfer system secretin TraK | - |
| LZM82_RS10740 (LZM82_10740) | 2376471..2377097 | - | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| LZM82_RS10745 (LZM82_10745) | 2377094..2377375 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2287647..2420917 | 133270 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35548.82 Da Isoelectric Point: 4.9081
>T230634 WP_000356587.1 NZ_CP090399:c2372264-2371326 [Vibrio cholerae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T230634 NZ_CP125220:3602264-3602521 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
Antitoxin
Download Length: 264 a.a. Molecular weight: 30095.47 Da Isoelectric Point: 9.5097
>AT230634 WP_000095578.1 NZ_CP090399:c2373048-2372257 [Vibrio cholerae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT230634 NZ_CP125220:c3602439-3602107 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1U9VZ44 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1U9VYW4 |