Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4174775..4175394 Replicon chromosome
Accession NZ_CP090398
Organism Klebsiella pneumoniae strain F94

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LZG48_RS20730 Protein ID WP_002892050.1
Coordinates 4175176..4175394 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LZG48_RS20725 Protein ID WP_002892066.1
Coordinates 4174775..4175149 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG48_RS20715 (LZG48_20715) 4169927..4171120 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZG48_RS20720 (LZG48_20720) 4171143..4174289 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LZG48_RS20725 (LZG48_20725) 4174775..4175149 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LZG48_RS20730 (LZG48_20730) 4175176..4175394 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LZG48_RS20735 (LZG48_20735) 4175553..4176119 + 567 WP_002892030.1 maltose O-acetyltransferase -
LZG48_RS20740 (LZG48_20740) 4176091..4176231 - 141 WP_004147370.1 hypothetical protein -
LZG48_RS20745 (LZG48_20745) 4176252..4176722 + 471 WP_002892026.1 YlaC family protein -
LZG48_RS20750 (LZG48_20750) 4176697..4178148 - 1452 WP_234277249.1 PLP-dependent aminotransferase family protein -
LZG48_RS20755 (LZG48_20755) 4178249..4178947 + 699 WP_002892021.1 GNAT family protein -
LZG48_RS20760 (LZG48_20760) 4178944..4179084 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LZG48_RS20765 (LZG48_20765) 4179084..4179347 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230628 WP_002892050.1 NZ_CP090398:4175176-4175394 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230628 NZ_CP125220:825273-825686 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230628 WP_002892066.1 NZ_CP090398:4174775-4175149 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230628 NZ_CP125220:825026-825292 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References