Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 881061..881715 Replicon chromosome
Accession NZ_CP090398
Organism Klebsiella pneumoniae strain F94

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LZG48_RS04450 Protein ID WP_004144731.1
Coordinates 881308..881715 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LZG48_RS04445 Protein ID WP_002916312.1
Coordinates 881061..881327 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG48_RS04420 (LZG48_04420) 876217..877650 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LZG48_RS04425 (LZG48_04425) 877769..878497 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LZG48_RS04430 (LZG48_04430) 878547..878858 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LZG48_RS04435 (LZG48_04435) 879022..879681 + 660 WP_002916317.1 hemolysin III family protein -
LZG48_RS04440 (LZG48_04440) 879832..880815 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LZG48_RS04445 (LZG48_04445) 881061..881327 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LZG48_RS04450 (LZG48_04450) 881308..881715 + 408 WP_004144731.1 protein YgfX Toxin
LZG48_RS04455 (LZG48_04455) 881722..882243 - 522 WP_002916308.1 flavodoxin FldB -
LZG48_RS04460 (LZG48_04460) 882344..883240 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LZG48_RS04465 (LZG48_04465) 883263..883976 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZG48_RS04470 (LZG48_04470) 883982..885715 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T230618 WP_004144731.1 NZ_CP090398:881308-881715 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T230618 NZ_CP125094:c1708319-1708050 [Agrobacterium fabrum]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGATTATGAGTTCTGGCAAAGAACCGATGCTCGCATGGTCGAGAAAAT
AAACGACCTTATCCGAAATGCCAAACGCACGCCCTTTGCAGGGCTTGGGAAACCGGAGCCTCTGAAAGGCGATATGGCAG
GATATTGGTCTCGGCGGATTACCGCCGAGCATCGGTTTGTCTACCGTGTATCCGGGTCCGGAAGCGAGCAACGGCTGGAA
ATCATCCAGTGCCGCTTTCACTACCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230618 WP_002916312.1 NZ_CP090398:881061-881327 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230618 NZ_CP125094:c1708570-1708316 [Agrobacterium fabrum]
ATGGCGAATGTGCGATTCACCGAGTTCCGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAAACCCGCGCGCCATT
GCTCGTCACGCGGCAGGGTAAAGAGGCGGTCGTGGTGCTCGCCGAAGGGGAATATGAGAGCATGCAGGAAACGCTGCATC
TCCTGTCCAACCCGGCAAATGCCTCACGGCTTCGCGCGTCCATGGACGAACTTGAGCGCGATGATACCATAGAGCGGGAT
CCGACCGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References