Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4704620..4705136 Replicon chromosome
Accession NZ_CP090397
Organism Klebsiella pneumoniae strain F4

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LZG49_RS22650 Protein ID WP_004178374.1
Coordinates 4704620..4704904 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LZG49_RS22655 Protein ID WP_002886901.1
Coordinates 4704894..4705136 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG49_RS22625 (4700104) 4700104..4700367 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
LZG49_RS22630 (4700497) 4700497..4700670 + 174 WP_032408826.1 hypothetical protein -
LZG49_RS22635 (4700673) 4700673..4701416 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LZG49_RS22640 (4701773) 4701773..4703911 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LZG49_RS22645 (4704152) 4704152..4704616 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LZG49_RS22650 (4704620) 4704620..4704904 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZG49_RS22655 (4704894) 4704894..4705136 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZG49_RS22660 (4705214) 4705214..4707124 - 1911 WP_004178373.1 PRD domain-containing protein -
LZG49_RS22665 (4707147) 4707147..4708301 - 1155 WP_004178372.1 lactonase family protein -
LZG49_RS22670 (4708368) 4708368..4709108 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T230612 WP_004178374.1 NZ_CP090397:c4704904-4704620 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T230612 NZ_CP125088:c5248346-5247963 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT230612 WP_002886901.1 NZ_CP090397:c4705136-4704894 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230612 NZ_CP125088:c5248588-5248346 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References