Detailed information of TA system TA230608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2648592..2650180
• Replicon: chromosome
• Accession: NZ_CP090397
• Organism: Klebsiella pneumoniae strain F4

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LZG49_RS12925
• Protein ID: WP_004179815.1
• Coordinates: 2648592..2649914 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LZG49_RS12930
• Protein ID: WP_004176198.1
• Coordinates: 2649914..2650180 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZG49_RS12910 (2643648)	2643648..2646149	+	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-
LZG49_RS12915 (2646137)	2646137..2647141	+	1005	WP_004179822.1	fimbrial protein	-
LZG49_RS12920 (2647283)	2647283..2648575	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LZG49_RS12925 (2648592)	2648592..2649914	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
LZG49_RS12930 (2649914)	2649914..2650180	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LZG49_RS12935 (2650446)	2650446..2650772	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LZG49_RS12940 (2650769)	2650769..2651269	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LZG49_RS12945 (2651247)	2651247..2652626	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
LZG49_RS12950 (2652972)	2652972..2654126	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LZG49_RS12955 (2654107)	2654107..2655030	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T230608 WP_004179815.1 NZ_CP090397:c2649914-2648592 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T230608 NZ_CP125088:4068761-4068979 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT230608 WP_004176198.1 NZ_CP090397:c2650180-2649914 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT230608 NZ_CP125088:4068360-4068734 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG