Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 875227..875996 Replicon chromosome
Accession NZ_CP090397
Organism Klebsiella pneumoniae strain F4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LZG49_RS04340 Protein ID WP_094545032.1
Coordinates 875610..875996 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LZG49_RS04335 Protein ID WP_176450486.1
Coordinates 875227..875553 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG49_RS04305 (871086) 871086..872174 + 1089 WP_065523308.1 patatin-like phospholipase family protein -
LZG49_RS04310 (872310) 872310..872468 - 159 Protein_846 transposase -
LZG49_RS04315 (873140) 873140..873961 + 822 WP_065523307.1 DUF932 domain-containing protein -
LZG49_RS04320 (873994) 873994..874443 + 450 WP_094545028.1 antirestriction protein -
LZG49_RS04325 (874455) 874455..874934 + 480 WP_094545029.1 DNA repair protein RadC -
LZG49_RS04330 (874948) 874948..875169 + 222 WP_094545030.1 DUF987 domain-containing protein -
LZG49_RS04335 (875227) 875227..875553 + 327 WP_176450486.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZG49_RS04340 (875610) 875610..875996 + 387 WP_094545032.1 TA system toxin CbtA family protein Toxin
LZG49_RS04345 (876083) 876083..876922 + 840 WP_104466614.1 DUF4942 domain-containing protein -
LZG49_RS04350 (877263) 877263..878651 - 1389 WP_004181229.1 MFS transporter -
LZG49_RS04355 (878781) 878781..879710 + 930 WP_002916293.1 LysR family transcriptional regulator -
LZG49_RS04360 (880073) 880073..880876 - 804 WP_004181228.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(7-110)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14390.36 Da        Isoelectric Point: 8.0800

>T230599 WP_094545032.1 NZ_CP090397:875610-875996 [Klebsiella pneumoniae]
MQTTLPFMRAVSSRPSPVDVWQTLLTCLLEHHYGLTLNDTSFSDEQVIQQHIDAGISLSDALNFIVEKYELVRTDRPGFS
IREQSPFITAIDILRARKATGLMNRGTYKEVTAITRGQHPQASTSGKR

Download         Length: 387 bp

>T230599 NZ_CP125086:c4221253-4220870 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12089.69 Da        Isoelectric Point: 6.4749

>AT230599 WP_176450486.1 NZ_CP090397:875227-875553 [Klebsiella pneumoniae]
ISEPWWGLRHSASPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLMKQLELLLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYSTPIATA

Download         Length: 327 bp

>AT230599 NZ_CP125086:c4221495-4221253 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References