Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 830644..831301 Replicon chromosome
Accession NZ_CP090397
Organism Klebsiella pneumoniae strain F4

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LZG49_RS04120 Protein ID WP_002916310.1
Coordinates 830891..831301 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LZG49_RS04115 Protein ID WP_002916312.1
Coordinates 830644..830910 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG49_RS04090 (825800) 825800..827233 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
LZG49_RS04095 (827352) 827352..828080 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LZG49_RS04100 (828130) 828130..828441 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LZG49_RS04105 (828605) 828605..829264 + 660 WP_002916317.1 hemolysin III family protein -
LZG49_RS04110 (829415) 829415..830398 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
LZG49_RS04115 (830644) 830644..830910 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LZG49_RS04120 (830891) 830891..831301 + 411 WP_002916310.1 protein YgfX Toxin
LZG49_RS04125 (831308) 831308..831829 - 522 WP_064159432.1 flavodoxin FldB -
LZG49_RS04130 (831930) 831930..832826 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LZG49_RS04135 (832849) 832849..833562 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZG49_RS04140 (833568) 833568..835301 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T230598 WP_002916310.1 NZ_CP090397:830891-831301 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T230598 NZ_CP125086:c3751480-3751196 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230598 WP_002916312.1 NZ_CP090397:830644-830910 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230598 NZ_CP125086:c3751712-3751470 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References