230590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4637227..4637897 Replicon chromosome
Accession NZ_CP090393
Organism Klebsiella pneumoniae strain YZH2429

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag LY283_RS22820 Protein ID WP_023301398.1
Coordinates 4637227..4637559 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag LY283_RS22825 Protein ID WP_023301397.1
Coordinates 4637580..4637897 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY283_RS22795 (4632452) 4632452..4633124 + 673 Protein_4469 DUF4400 domain-containing protein -
LY283_RS22800 (4633135) 4633135..4634019 + 885 WP_004192285.1 RES domain-containing protein -
LY283_RS22805 (4634218) 4634218..4634406 - 189 Protein_4471 transposase -
LY283_RS22810 (4634423) 4634423..4635534 - 1112 Protein_4472 IS3 family transposase -
LY283_RS22815 (4635933) 4635933..4636793 - 861 WP_023301399.1 hypothetical protein -
LY283_RS22820 (4637227) 4637227..4637559 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
LY283_RS22825 (4637580) 4637580..4637897 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LY283_RS22830 (4637916) 4637916..4638137 - 222 WP_023301396.1 DUF987 domain-containing protein -
LY283_RS22835 (4638146) 4638146..4638628 - 483 WP_023301395.1 RadC family protein -
LY283_RS22840 (4638637) 4638637..4639095 - 459 WP_023301394.1 antirestriction protein -
LY283_RS22845 (4639181) 4639181..4639417 - 237 WP_032446575.1 DUF905 domain-containing protein -
LY283_RS22850 (4639495) 4639495..4639905 - 411 WP_023301393.1 hypothetical protein -
LY283_RS22855 (4639972) 4639972..4640409 - 438 WP_023301392.1 hypothetical protein -
LY283_RS22860 (4640451) 4640451..4640987 - 537 WP_023301391.1 DUF4339 domain-containing protein -
LY283_RS22865 (4641013) 4641013..4641723 - 711 WP_023301390.1 DeoR family transcriptional regulator -
LY283_RS22870 (4641932) 4641932..4642756 - 825 WP_023301389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T230590 WP_023301398.1 NZ_CP090393:c4637559-4637227 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T230590 NZ_CP125084:c67486-67199 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACATATACCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGAACAAGCTAGATAAGACTATTCAGCAGCAGTTTGC
AAAGAAACTTAAAAAGTGCTGTGAAAACCCACACATTCCTTCAGCAAAACTACGTGGTATAAAGGATTGCTATAAAATAA
AACTGCGAGCATCTGGTTTTCGCCTCGTCTATCAGGTCATAGATAATCAACTTATAATTGCTATTGTGGCTGTAGGCAAA
CGGGAGCGCAGTGACGTTTATACACTGGCGAGTGAACGTATGAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT230590 WP_023301397.1 NZ_CP090393:c4637897-4637580 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT230590 NZ_CP125084:c67734-67483 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACATATCATTCTGAGTGACACGACTGCCAGCGTCAGTGAATTGAAAAAAAACCCGATGGCCACAGTCAGCGCAGG
TGACGGGTTCCCAGTAGCGATTCTTAACCGGAACCAGCCAGCTTTCTATTGCGTGCCTGCGGAACTCTACGAAAAGATGC
TTGATGCGCTGGATGATCAGGAACTCATTAAACTGGTTGCAGAACGCAGTAATCAACCGCTGTTTGATATGGACCTGGAG
AAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References