Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4001051..4001670 Replicon chromosome
Accession NZ_CP090393
Organism Klebsiella pneumoniae strain YZH2429

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LY283_RS19720 Protein ID WP_002892050.1
Coordinates 4001452..4001670 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LY283_RS19715 Protein ID WP_002892066.1
Coordinates 4001051..4001425 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY283_RS19705 (3996203) 3996203..3997396 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LY283_RS19710 (3997419) 3997419..4000565 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LY283_RS19715 (4001051) 4001051..4001425 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LY283_RS19720 (4001452) 4001452..4001670 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LY283_RS19725 (4001833) 4001833..4002399 + 567 WP_002892030.1 maltose O-acetyltransferase -
LY283_RS19730 (4002371) 4002371..4002511 - 141 WP_004147370.1 hypothetical protein -
LY283_RS19735 (4002532) 4002532..4003002 + 471 WP_002892026.1 YlaC family protein -
LY283_RS19740 (4002977) 4002977..4004428 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LY283_RS19745 (4004529) 4004529..4005227 + 699 WP_002892021.1 GNAT family protein -
LY283_RS19750 (4005224) 4005224..4005364 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LY283_RS19755 (4005364) 4005364..4005627 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230588 WP_002892050.1 NZ_CP090393:4001452-4001670 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230588 NZ_CP125083:4825002-4825412 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATTCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230588 WP_002892066.1 NZ_CP090393:4001051-4001425 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230588 NZ_CP125083:4824755-4825021 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References