Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2597455..2599043 Replicon chromosome
Accession NZ_CP090393
Organism Klebsiella pneumoniae strain YZH2429

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag LY283_RS12785 Protein ID WP_004190166.1
Coordinates 2597455..2598777 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LY283_RS12790 Protein ID WP_002904790.1
Coordinates 2598777..2599043 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY283_RS12770 (2592511) 2592511..2595012 + 2502 WP_114263676.1 fimbria/pilus outer membrane usher protein -
LY283_RS12775 (2595000) 2595000..2596004 + 1005 WP_004190163.1 fimbrial protein -
LY283_RS12780 (2596146) 2596146..2597438 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LY283_RS12785 (2597455) 2597455..2598777 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
LY283_RS12790 (2598777) 2598777..2599043 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LY283_RS12795 (2599308) 2599308..2599634 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LY283_RS12800 (2599631) 2599631..2600131 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LY283_RS12805 (2600109) 2600109..2601488 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LY283_RS12810 (2601834) 2601834..2602988 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LY283_RS12815 (2602969) 2602969..2603892 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T230586 WP_004190166.1 NZ_CP090393:c2598777-2597455 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T230586 NZ_CP125083:4385798-4386145 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT230586 WP_002904790.1 NZ_CP090393:c2599043-2598777 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT230586 NZ_CP125083:4386199-4386444 [Klebsiella pneumoniae subsp. pneumoniae]
ATTGCAGCGAAAGCGGCAGAGATACGCCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGA
GATGGCTGCGGCTATGGGGGTAAAGCAGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCC
TAAAAAGCTACATTGCGGCATTGGGGGGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAAT
TTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References