Detailed information of TA system TA230586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2597455..2599043
• Replicon: chromosome
• Accession: NZ_CP090393
• Organism: Klebsiella pneumoniae strain YZH2429

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486KW17
• Locus tag: LY283_RS12785
• Protein ID: WP_004190166.1
• Coordinates: 2597455..2598777 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: LY283_RS12790
• Protein ID: WP_002904790.1
• Coordinates: 2598777..2599043 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LY283_RS12770 (2592511)	2592511..2595012	+	2502	WP_114263676.1	fimbria/pilus outer membrane usher protein	-
LY283_RS12775 (2595000)	2595000..2596004	+	1005	WP_004190163.1	fimbrial protein	-
LY283_RS12780 (2596146)	2596146..2597438	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LY283_RS12785 (2597455)	2597455..2598777	-	1323	WP_004190166.1	type II toxin-antitoxin system HipA family toxin	Toxin
LY283_RS12790 (2598777)	2598777..2599043	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LY283_RS12795 (2599308)	2599308..2599634	-	327	WP_004143476.1	hydroxyisourate hydrolase	-
LY283_RS12800 (2599631)	2599631..2600131	-	501	WP_004190169.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LY283_RS12805 (2600109)	2600109..2601488	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LY283_RS12810 (2601834)	2601834..2602988	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LY283_RS12815 (2602969)	2602969..2603892	-	924	WP_004190172.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T230586 WP_004190166.1 NZ_CP090393:c2598777-2597455 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T230586 NZ_CP125083:4385798-4386145 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT230586 WP_002904790.1 NZ_CP090393:c2599043-2598777 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT230586 NZ_CP125083:4386199-4386444 [Klebsiella pneumoniae subsp. pneumoniae]
ATTGCAGCGAAAGCGGCAGAGATACGCCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGA
GATGGCTGCGGCTATGGGGGTAAAGCAGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCC
TAAAAAGCTACATTGCGGCATTGGGGGGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAAT
TTGTGA

Structures

Toxin

• AlphaFold DB: A0A486KW17

Antitoxin

• AlphaFold DB: A0A0H3GXD8