Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 53671..54407 Replicon plasmid pYUYZH22127-1
Accession NZ_CP090390
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag LZC40_RS26180 Protein ID WP_003026803.1
Coordinates 53925..54407 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LZC40_RS26175 Protein ID WP_003026799.1
Coordinates 53671..53937 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS26130 49736..50098 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
LZC40_RS26135 50148..50498 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
LZC40_RS26140 50856..51125 + 270 WP_004152102.1 hypothetical protein -
LZC40_RS26145 51113..51688 + 576 WP_004152103.1 hypothetical protein -
LZC40_RS26150 51719..52212 + 494 Protein_50 DNA-binding protein -
LZC40_RS26155 52256..52624 + 369 WP_004152105.1 hypothetical protein -
LZC40_RS26160 52658..52861 + 204 WP_004152106.1 HHA domain-containing protein -
LZC40_RS26165 52910..53167 + 258 WP_004152107.1 hypothetical protein -
LZC40_RS26170 53243..53497 + 255 WP_004152108.1 hypothetical protein -
LZC40_RS26175 53671..53937 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LZC40_RS26180 53925..54407 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
LZC40_RS26185 54615..55961 + 1347 WP_077253535.1 ISNCY family transposase -
LZC40_RS26190 56010..56405 + 396 WP_004143398.1 helix-turn-helix domain-containing protein -
LZC40_RS26195 56553..57718 - 1166 Protein_59 IS3 family transposase -
LZC40_RS26200 57895..58857 - 963 WP_004152113.1 zinc metalloprotease HtpX -
LZC40_RS26205 58844..59332 - 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / qnrB1 / tet(A) / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / dfrA14 - 1..256194 256194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T230572 WP_003026803.1 NZ_CP090390:53925-54407 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T230572 NZ_CP124968:c131157-130876 [Agrobacterium tumefaciens]
ATGATCCGTTCTTTCAAAAACAAGCTGGCCGCATCGATTGACGACGGATCTGTGAAGAAGGTCTTTCCCGCCGATCTCGT
ACGCCGCGCCCAGCAGCTGCTCACGATCCTGGATGCGGCGACCACGGTAGAAGACCTTCGCTCACCGCCCGGCAATCGTT
TGGAAAAGCTGTCCGGCGATCGTGAGGGCCAATATTCGATCCGGATCAACAAGCAGTGGCGCATCTGCTTCGTCTGGACG
GAAGCAGGGCCGGAAAGCGTGGAAATAACCGACTATCACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT230572 WP_003026799.1 NZ_CP090390:53671-53937 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT230572 NZ_CP124968:c130820-130521 [Agrobacterium tumefaciens]
ATGACAATCAGTAAATTGCCTCCGATCCATCCGGGCGAAATCCTGCGGGAACTCTATCTTGAGCCGCTGGGGATGTCGGC
TTACGCTCTTGCAAGGCACCTCAATATTCCGCGCACCCGCATAGAACGGATTGCGGGAGAGAAACTTGGTATCACCGCCG
ACACCGCCTTGCGCCTTGCAAAGTTTTTCAAGACCACACCGGAATATTGGCTGAACTTGCAGAACGCCTTCGACATTAAG
GTGGCGGCTGTGAGGCTGGAAGCGGACCTTGCCAATATCAAGGAACTGGAAGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References