Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5210295..5210920 Replicon chromosome
Accession NZ_CP090389
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag LZC40_RS25535 Protein ID WP_004187928.1
Coordinates 5210295..5210678 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LZC40_RS25540 Protein ID WP_004150355.1
Coordinates 5210678..5210920 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS25520 (5207661) 5207661..5208563 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LZC40_RS25525 (5208560) 5208560..5209195 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LZC40_RS25530 (5209192) 5209192..5210121 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LZC40_RS25535 (5210295) 5210295..5210678 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
LZC40_RS25540 (5210678) 5210678..5210920 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LZC40_RS25545 (5211114) 5211114..5212031 + 918 WP_004187929.1 alpha/beta hydrolase -
LZC40_RS25550 (5212045) 5212045..5212986 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LZC40_RS25555 (5213031) 5213031..5213468 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LZC40_RS25560 (5213465) 5213465..5214325 - 861 WP_004146232.1 virulence factor BrkB family protein -
LZC40_RS25565 (5214319) 5214319..5214918 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T230571 WP_004187928.1 NZ_CP090389:c5210678-5210295 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T230571 NZ_CP124967:c2314784-2314269 [Agrobacterium tumefaciens]
GTGGCTTTATCGGCCCCCGAACTGCTCACCGCGGCGCATGACGTTTCTGAATTCTCTTGTGGTACGCCGACGCTCGATCA
TTGGCTGAAGACTCGTGCCCTATCCAATCAGCAGAAGGGTTTTACCGTCGTACTCGTCGTACACGAGGCTGGGCGCGTGG
TTGGATACTACGGTCTGGCGCCGACCGCCGTAGTGCCGGCGATCCTGCCACGCTCGATCCGCACCGGCCAGCCGCCTGAC
CCCGTGCCTTGCCTTCTCCTCGGTCAGCTTGCCACGGATGAAGCCTGGGCCGGGCAGGGGATCGGGACCGGCCTTGTCAA
GCACGCGCTCCAGCGGTGTGTTCAGGCCGCGAATCTGATCGGAGGACGCGCTCTGATGGTCAACGCCATCGATGACGAAG
CCGCCCGCTTCTGGCAGCGTCGAGGCTTTATGTCCTCGAAGGACGACCCGCTCGTCCTCTTCCGCTCTATTGCAGACATC
GCCGCGTCCTTCGCTGAAGCCCATGCACCAGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT230571 WP_004150355.1 NZ_CP090389:c5210920-5210678 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT230571 NZ_CP124967:c2315087-2314788 [Agrobacterium tumefaciens]
ATGGCCACCATCGTTGAACGCAAGGAATACCCGATCTCGATGCGCCTGCCGGAAGCGGACGTCGCAATGATCGACCGCGC
CGCCACCCTGCGCGGACGCTCCCGCACCGACTTTGTGCGGGACGCCGCCGTGCGCGCGGCCGAGGATGTGTTGATGGAAA
ACCGGTTGATCCGCATGAGCCCCGAGGGCTTTGCCGAATTCATGGATGTTCTCGCTGCCCCGGCGGCTCCGGTCGCCGAG
ATGGTGGAACTGGCGCAACGGCCGGCGCCTTGGGAAACCGGCTATGAGCCGAAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References