Detailed information of TA system TA230570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4888008..4889689
• Replicon: chromosome
• Accession: NZ_CP090389
• Organism: Klebsiella pneumoniae strain YZH22127

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: LZC40_RS24050
• Protein ID: WP_002885155.1
• Coordinates: 4888008..4888925 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A2L1C4M5
• Locus tag: LZC40_RS24055
• Protein ID: WP_004192584.1
• Coordinates: 4888931..4889689 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZC40_RS24030 (4883314)	4883314..4884834	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LZC40_RS24035 (4884831)	4884831..4885829	+	999	WP_002885172.1	ribose ABC transporter permease	-
LZC40_RS24040 (4885860)	4885860..4886801	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LZC40_RS24045 (4886876)	4886876..4887883	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
LZC40_RS24050 (4888008)	4888008..4888925	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LZC40_RS24055 (4888931)	4888931..4889689	-	759	WP_004192584.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LZC40_RS24060 (4889775)	4889775..4890503	-	729	WP_002885152.1	response regulator transcription factor	-
LZC40_RS24065 (4890776)	4890776..4892923	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LZC40_RS24070 (4893153)	4893153..4893839	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T230570 WP_002885155.1 NZ_CP090389:c4888925-4888008 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T230570 NZ_CP124967:2109602-2109907 [Agrobacterium tumefaciens]
ATGCCACTTGTGACACGCGATTACGATGCTGCCCGCTACCTTGATAGTGACGAAGCGCTTGCCGCTTACATCGCCGACGC
CACAGAGAGCGGCGATGCACAGGAGCTCGCCCATGCGCTGGGCGTCGTGGCGCGGGCCAAGGGTATGACTGACCTTTCGA
GACAAACCGGCCTTCCCCGCCAGACCTTGTACAAGGCGCTGAGCGGCGAGGGAAATCCGGAACTGGCGACGATTGCCAAG
GTCGCCGACGCGCTGGGCTACAGGCTCTCGCTGGTGGCGAAACCGCCTGCAGACACGGCCGCCTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT230570 WP_004192584.1 NZ_CP090389:c4889689-4888931 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT230570 NZ_CP124967:2109301-2109597 [Agrobacterium tumefaciens]
ATGCTCACGATCCGGGAAACAAGCGAGTTTGCCGACTGGCTGGCGGGTCTGCGCGATGTGCAGGCGCGCGCCCGCATCGC
ACGCCGCATTTACCGGCTGGCGGACGGCAATCCCGGAGACGTGAAACCGGTTGGCGAAGGCGTCAGCGAACTCAGGATCG
ACCTTGGACCCGGATATCGGGTCTATTTTGTCCGGCACGGCGATGTCGTCATCATATTGCTGTGTGGCGGCGACAAGGCA
TCGCAACCCCGCGACATCGCCAGAGCCAAGAAACTGGCCAGAGCGCTCAAGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A2L1C4M5