Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4723532..4724048 Replicon chromosome
Accession NZ_CP090389
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag LZC40_RS23215 Protein ID WP_004192395.1
Coordinates 4723532..4723816 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag LZC40_RS23220 Protein ID WP_004192397.1
Coordinates 4723806..4724048 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS23190 (4718949) 4718949..4719212 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LZC40_RS23195 (4719342) 4719342..4719515 + 174 WP_002886906.1 hypothetical protein -
LZC40_RS23200 (4719518) 4719518..4720261 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LZC40_RS23205 (4720618) 4720618..4722756 + 2139 WP_114263766.1 anaerobic ribonucleoside-triphosphate reductase -
LZC40_RS23210 (4723064) 4723064..4723528 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LZC40_RS23215 (4723532) 4723532..4723816 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZC40_RS23220 (4723806) 4723806..4724048 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZC40_RS23225 (4724126) 4724126..4726036 - 1911 WP_004152270.1 PRD domain-containing protein -
LZC40_RS23230 (4726059) 4726059..4727213 - 1155 WP_004178372.1 lactonase family protein -
LZC40_RS23235 (4727280) 4727280..4728020 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T230569 WP_004192395.1 NZ_CP090389:c4723816-4723532 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T230569 NZ_CP124967:2109301-2109597 [Agrobacterium tumefaciens]
ATGCTCACGATCCGGGAAACAAGCGAGTTTGCCGACTGGCTGGCGGGTCTGCGCGATGTGCAGGCGCGCGCCCGCATCGC
ACGCCGCATTTACCGGCTGGCGGACGGCAATCCCGGAGACGTGAAACCGGTTGGCGAAGGCGTCAGCGAACTCAGGATCG
ACCTTGGACCCGGATATCGGGTCTATTTTGTCCGGCACGGCGATGTCGTCATCATATTGCTGTGTGGCGGCGACAAGGCA
TCGCAACCCCGCGACATCGCCAGAGCCAAGAAACTGGCCAGAGCGCTCAAGGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT230569 WP_004192397.1 NZ_CP090389:c4724048-4723806 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT230569 NZ_CP124967:2109602-2109907 [Agrobacterium tumefaciens]
ATGCCACTTGTGACACGCGATTACGATGCTGCCCGCTACCTTGATAGTGACGAAGCGCTTGCCGCTTACATCGCCGACGC
CACAGAGAGCGGCGATGCACAGGAGCTCGCCCATGCGCTGGGCGTCGTGGCGCGGGCCAAGGGTATGACTGACCTTTCGA
GACAAACCGGCCTTCCCCGCCAGACCTTGTACAAGGCGCTGAGCGGCGAGGGAAATCCGGAACTGGCGACGATTGCCAAG
GTCGCCGACGCGCTGGGCTACAGGCTCTCGCTGGTGGCGAAACCGCCTGCAGACACGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References