230568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4637224..4637894 Replicon chromosome
Accession NZ_CP090389
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag LZC40_RS22825 Protein ID WP_023301398.1
Coordinates 4637224..4637556 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag LZC40_RS22830 Protein ID WP_023301397.1
Coordinates 4637577..4637894 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS22800 (4632449) 4632449..4633121 + 673 Protein_4470 DUF4400 domain-containing protein -
LZC40_RS22805 (4633132) 4633132..4634016 + 885 WP_004192285.1 RES domain-containing protein -
LZC40_RS22810 (4634215) 4634215..4634403 - 189 Protein_4472 transposase -
LZC40_RS22815 (4634420) 4634420..4635531 - 1112 Protein_4473 IS3 family transposase -
LZC40_RS22820 (4635930) 4635930..4636790 - 861 WP_023301399.1 hypothetical protein -
LZC40_RS22825 (4637224) 4637224..4637556 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
LZC40_RS22830 (4637577) 4637577..4637894 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LZC40_RS22835 (4637913) 4637913..4638134 - 222 WP_023301396.1 DUF987 domain-containing protein -
LZC40_RS22840 (4638143) 4638143..4638625 - 483 WP_023301395.1 RadC family protein -
LZC40_RS22845 (4638634) 4638634..4639092 - 459 WP_023301394.1 antirestriction protein -
LZC40_RS22850 (4639178) 4639178..4639414 - 237 WP_032446575.1 DUF905 domain-containing protein -
LZC40_RS22855 (4639492) 4639492..4639902 - 411 WP_023301393.1 hypothetical protein -
LZC40_RS22860 (4639969) 4639969..4640406 - 438 WP_023301392.1 hypothetical protein -
LZC40_RS22865 (4640448) 4640448..4640984 - 537 WP_023301391.1 DUF4339 domain-containing protein -
LZC40_RS22870 (4641010) 4641010..4641720 - 711 WP_023301390.1 DeoR family transcriptional regulator -
LZC40_RS22875 (4641929) 4641929..4642753 - 825 WP_023301389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T230568 WP_023301398.1 NZ_CP090389:c4637556-4637224 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T230568 NZ_CP124967:c570802-570515 [Agrobacterium tumefaciens]
GTGCTGCCGCGCAGTTCGGATTTCACCAGGCAATTTATCAAGGACTGGCAACGGCTGAACAATTCGGGGCGTTATGACAT
GGTGAAACTGAAGGAGATCATGCTCCTTCTCATTGCCAACGAAGCGCCATTACCGGCGCAGTTTCGTGACCATGAATTGA
CCGGAGAATGGCACGATCATCGCGAATGCCATGTCGGCGGGGACTTTCTGTTGATCTACAAACTTGATGAGAAGCAGAAC
CTTCTCATCTTCACCCGCGCAGGAACGCACGCCGAGCTTTTCAGGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT230568 WP_023301397.1 NZ_CP090389:c4637894-4637577 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT230568 NZ_CP124967:c571122-570847 [Agrobacterium tumefaciens]
ATGACCGCAAATGCTTATGTGAGAGCGCGCATCGATCAGGCACTCAAGGACGACGCGACTGCCGTGCTCGACAGTCTGGG
ACTGACTGTTTCCGACGTCATGCGAATGATGCTGACGCGCATTGCCCGAGAAAAAGCACTGCCGATAGAACTGACGCAAC
CGAACGCTGAAACGCTCGCCGCGATTGAAGAAGCGCGCGCCATCGCGGCTGCCAGGCGCAATCGTTTCGGCACGGCGCAA
GCCTTGTTTGACGCCCTTGATGGTAACAAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References