Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4001048..4001667 Replicon chromosome
Accession NZ_CP090389
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LZC40_RS19720 Protein ID WP_002892050.1
Coordinates 4001449..4001667 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LZC40_RS19715 Protein ID WP_002892066.1
Coordinates 4001048..4001422 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS19705 (3996200) 3996200..3997393 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZC40_RS19710 (3997416) 3997416..4000562 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LZC40_RS19715 (4001048) 4001048..4001422 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LZC40_RS19720 (4001449) 4001449..4001667 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LZC40_RS19725 (4001830) 4001830..4002396 + 567 WP_002892030.1 maltose O-acetyltransferase -
LZC40_RS19730 (4002368) 4002368..4002508 - 141 WP_004147370.1 hypothetical protein -
LZC40_RS19735 (4002529) 4002529..4002999 + 471 WP_002892026.1 YlaC family protein -
LZC40_RS19740 (4002974) 4002974..4004425 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LZC40_RS19745 (4004526) 4004526..4005224 + 699 WP_002892021.1 GNAT family protein -
LZC40_RS19750 (4005221) 4005221..4005361 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LZC40_RS19755 (4005361) 4005361..4005624 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T230566 WP_002892050.1 NZ_CP090389:4001449-4001667 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T230566 NZ_CP124967:c321422-321153 [Agrobacterium tumefaciens]
TTGATCTGGAAAATTGAGTTTCAGCGCGCTGCCGTCAAGCAACTGGGCGCTTTGACGAAAAGCGATGCCAATCGCATCGT
TTCTTTTCTGACGGACCGCATTGCCAGAGATGGCAACCCTCGAAGGACCGGCGCCGCCCTTCAAGGCTCCGAACTCGGAA
ATTTCTGGCGCTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTCGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATCTACCGATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT230566 WP_002892066.1 NZ_CP090389:4001048-4001422 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT230566 NZ_CP124967:c321639-321406 [Agrobacterium tumefaciens]
ATGAGCAAACAGACGGCCATCCGCCTGCCTGATGAGACCTATGAGCGGCTGAAGGCGCTTTCCGAGCGCACCGGCCGCAC
ATCCGCCTATTACATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGATCTTTATCTTGCGGAGGAGGCGACGC
GGCAGCGCATCGCCAATAAAGAACGCACCTATACTCTGGAAGAAGTGATGCGTGATCTTGATCTGGAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References