Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833696..834353 Replicon chromosome
Accession NZ_CP090389
Organism Klebsiella pneumoniae strain YZH22127

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LZC40_RS04180 Protein ID WP_002916310.1
Coordinates 833943..834353 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LZC40_RS04175 Protein ID WP_002916312.1
Coordinates 833696..833962 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZC40_RS04150 (828852) 828852..830285 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LZC40_RS04155 (830404) 830404..831132 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LZC40_RS04160 (831182) 831182..831493 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LZC40_RS04165 (831657) 831657..832316 + 660 WP_002916317.1 hemolysin III family protein -
LZC40_RS04170 (832467) 832467..833450 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LZC40_RS04175 (833696) 833696..833962 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LZC40_RS04180 (833943) 833943..834353 + 411 WP_002916310.1 protein YgfX Toxin
LZC40_RS04185 (834360) 834360..834881 - 522 WP_002916308.1 flavodoxin FldB -
LZC40_RS04190 (834982) 834982..835878 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LZC40_RS04195 (835901) 835901..836614 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZC40_RS04200 (836620) 836620..838353 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T230555 WP_002916310.1 NZ_CP090389:833943-834353 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T230555 NZ_CP124923:c2756801-2756658 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT230555 WP_002916312.1 NZ_CP090389:833696-833962 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT230555 NZ_CP124923:2756538-2756725 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References