230550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2179111..2180936 Replicon chromosome
Accession NZ_CP090387
Organism Vibrio cholerae strain GXFL1-4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LY388_RS15280 Protein ID WP_199358544.1
Coordinates 2179111..2180472 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LY388_RS15285 Protein ID WP_032472658.1
Coordinates 2180469..2180936 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY388_RS15250 (LY388_15250) 2174643..2176307 + 1665 WP_000879550.1 DNA repair protein RecN -
LY388_RS15255 (LY388_15255) 2176466..2176825 + 360 WP_001160912.1 outer membrane protein assembly factor BamE -
LY388_RS15260 (LY388_15260) 2176903..2177208 - 306 WP_001929603.1 RnfH family protein -
LY388_RS15265 (LY388_15265) 2177211..2177645 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
LY388_RS15270 (LY388_15270) 2177829..2178314 + 486 WP_000162689.1 SsrA-binding protein SmpB -
LY388_RS15280 (LY388_15280) 2179111..2180472 + 1362 WP_199358544.1 type II toxin-antitoxin system HipA family toxin Toxin
LY388_RS15285 (LY388_15285) 2180469..2180936 + 468 WP_032472658.1 helix-turn-helix transcriptional regulator Antitoxin
LY388_RS15290 (LY388_15290) 2181364..2181942 + 579 WP_000109982.1 class I SAM-dependent methyltransferase -
LY388_RS15295 (LY388_15295) 2181946..2184882 + 2937 WP_199358543.1 DEAD/DEAH box helicase family protein -
LY388_RS15300 (LY388_15300) 2184953..2185654 + 702 Protein_1907 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51345.26 Da        Isoelectric Point: 4.9814

>T230550 WP_199358544.1 NZ_CP090387:2179111-2180472 [Vibrio cholerae]
MEELTVQAFIRGEWRDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TNGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYKFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T230550 NZ_CP124923:c321580-321485 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17073.60 Da        Isoelectric Point: 10.7084

>AT230550 WP_032472658.1 NZ_CP090387:2180469-2180936 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT230550 NZ_CP124923:321386-321450 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References