Detailed information of TA system TA023055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 69241..69763
• Replicon: plasmid pCT02021853_74
• Accession: NC_011204
• Organism: Salmonella enterica subsp. enterica serovar Dublin str. CT 02021853

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G3CAN5
• Locus tag: SED_RS00405
• Protein ID: WP_000220560.1
• Coordinates: 69241..69522 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: SED_RS00410
• Protein ID: WP_000121743.1
• Coordinates: 69512..69763 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SED_RS00370	65074..66255	-	1182	WP_000539536.1	relaxase/mobilization nuclease domain-containing protein	-
SED_RS00375	66258..66803	-	546	WP_000757691.1	hypothetical protein	-
SED_RS26555	66798..66872	-	75	Protein_78	DNA distortion polypeptide 3	-
SED_RS24250	67129..67401	-	273	WP_000160399.1	hypothetical protein	-
SED_RS26560	67414..67611	-	198	WP_001675595.1	hypothetical protein	-
SED_RS24255	67633..67812	-	180	WP_001575529.1	hypothetical protein	-
SED_RS00385	67855..68184	-	330	WP_000866650.1	hypothetical protein	-
SED_RS00390	68277..68492	-	216	WP_001180117.1	hypothetical protein	-
SED_RS00395	68482..68727	-	246	WP_000356542.1	hypothetical protein	-
SED_RS00400	68772..69095	-	324	WP_001181909.1	hypothetical protein	-
SED_RS00405	69241..69522	-	282	WP_000220560.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SED_RS00410	69512..69763	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
SED_RS00415	70977..71813	+	837	WP_001575533.1	replication initiation protein	-
SED_RS00420	71853..72299	+	447	WP_001074381.1	hypothetical protein	-
SED_RS00425	72367..72789	+	423	WP_000202949.1	hypothetical protein	-
SED_RS00430	73428..73658	-	231	WP_000051066.1	partitioning protein	-
SED_RS00435	73710..74330	-	621	WP_000864788.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74551	74551

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T23055 WP_000220560.1 NC_011204:c69522-69241 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T23055 NC_011204:c69522-69241 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT23055 WP_000121743.1 NC_011204:c69763-69512 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT23055 NC_011204:c69763-69512 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
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Structures

Toxin

• AlphaFold DB: G3CAN5

Antitoxin

• AlphaFold DB: A0A3S5I301