230549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1034161..1034659 Replicon chromosome
Accession NZ_CP090386
Organism Vibrio cholerae strain GXFL1-4

Toxin (Protein)


Gene name - Uniprot ID A0A151JG87
Locus tag LY388_RS04835 Protein ID WP_000589153.1
Coordinates 1034393..1034659 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LY388_RS04830 Protein ID WP_199358704.1
Coordinates 1034161..1034406 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY388_RS04790 (LY388_04790) 1029600..1030013 - 414 WP_199358715.1 GNAT family N-acetyltransferase -
LY388_RS04795 (LY388_04795) 1030053..1030115 - 63 Protein_955 acetyltransferase -
LY388_RS04800 (LY388_04800) 1030561..1031331 - 771 WP_199358716.1 alpha/beta hydrolase -
LY388_RS04805 (LY388_04805) 1031495..1032193 - 699 WP_046126203.1 HAD family phosphatase -
LY388_RS04810 (LY388_04810) 1032303..1032761 - 459 WP_080476635.1 GNAT family N-acetyltransferase -
LY388_RS04815 (LY388_04815) 1032913..1033542 - 630 WP_001009011.1 type B chloramphenicol O-acetyltransferase -
LY388_RS04820 (LY388_04820) 1033818..1033928 - 111 WP_229765366.1 DUF3709 domain-containing protein -
LY388_RS04825 (LY388_04825) 1034046..1034156 - 111 Protein_961 DUF3265 domain-containing protein -
LY388_RS04830 (LY388_04830) 1034161..1034406 - 246 WP_199358704.1 CopG family transcriptional regulator Antitoxin
LY388_RS04835 (LY388_04835) 1034393..1034659 - 267 WP_000589153.1 BrnT family toxin Toxin
LY388_RS04840 (LY388_04840) 1034726..1034836 - 111 WP_142618709.1 DUF3265 domain-containing protein -
LY388_RS04845 (LY388_04845) 1034833..1035402 - 570 WP_000686204.1 flavodoxin family protein -
LY388_RS04850 (LY388_04850) 1035551..1036555 - 1005 WP_000964928.1 LD-carboxypeptidase -
LY388_RS04855 (LY388_04855) 1036709..1037095 - 387 WP_000703159.1 VOC family protein -
LY388_RS04860 (LY388_04860) 1037353..1037574 - 222 WP_032478112.1 DUF1289 domain-containing protein -
LY388_RS04865 (LY388_04865) 1038207..1038683 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
LY388_RS04870 (LY388_04870) 1039020..1039484 + 465 WP_057563740.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 992905..1075334 82429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10062.32 Da        Isoelectric Point: 7.3171

>T230549 WP_000589153.1 NZ_CP090386:c1034659-1034393 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGANIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T230549 NZ_CP124922:62637-62747 [Enterococcus faecalis]
GTGTTATTTGTGAAAGATTTAATGTCGTTGGTTATCGCACCGATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGT
GTTGGACGAGGAAGACGATAACCGAAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9520.80 Da        Isoelectric Point: 6.2241

>AT230549 WP_199358704.1 NZ_CP090386:c1034406-1034161 [Vibrio cholerae]
MKAHEFDSKFESDDDDIVMDLDLSQAKRPMYKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT230549 NZ_CP124922:c62851-62787 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JG87

Antitoxin

Source ID Structure

References