Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1020765..1021324 | Replicon | chromosome |
| Accession | NZ_CP090386 | ||
| Organism | Vibrio cholerae strain GXFL1-4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HHK2 |
| Locus tag | LY388_RS04710 | Protein ID | WP_000578471.1 |
| Coordinates | 1021046..1021324 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | LY388_RS04705 | Protein ID | WP_000381183.1 |
| Coordinates | 1020765..1021049 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LY388_RS04675 (LY388_04675) | 1016366..1016866 | - | 501 | WP_199358713.1 | hypothetical protein | - |
| LY388_RS04680 (LY388_04680) | 1017020..1017526 | - | 507 | WP_002053776.1 | GNAT family N-acetyltransferase | - |
| LY388_RS04685 (LY388_04685) | 1017774..1017995 | - | 222 | WP_233357546.1 | DUF1289 domain-containing protein | - |
| LY388_RS04690 (LY388_04690) | 1018199..1018501 | - | 303 | WP_234115905.1 | pullulanase | - |
| LY388_RS04695 (LY388_04695) | 1019208..1019708 | - | 501 | WP_234115906.1 | hypothetical protein | - |
| LY388_RS04700 (LY388_04700) | 1020054..1020515 | - | 462 | WP_231501962.1 | lipocalin family protein | - |
| LY388_RS04705 (LY388_04705) | 1020765..1021049 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LY388_RS04710 (LY388_04710) | 1021046..1021324 | + | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| LY388_RS04715 (LY388_04715) | 1021463..1021930 | - | 468 | WP_199358709.1 | OsmC family protein | - |
| LY388_RS04720 (LY388_04720) | 1022082..1022549 | - | 468 | WP_233357544.1 | hypothetical protein | - |
| LY388_RS04725 (LY388_04725) | 1022651..1023205 | - | 555 | WP_142547361.1 | hypothetical protein | - |
| LY388_RS04730 (LY388_04730) | 1023473..1023709 | - | 237 | Protein_942 | DUF3709 domain-containing protein | - |
| LY388_RS04735 (LY388_04735) | 1023985..1024953 | - | 969 | WP_199358711.1 | YiiX/YebB-like N1pC/P60 family cysteine hydrolase | - |
| LY388_RS04740 (LY388_04740) | 1024971..1025033 | - | 63 | Protein_944 | acetyltransferase | - |
| LY388_RS04745 (LY388_04745) | 1025222..1025482 | - | 261 | WP_071170822.1 | DUF3709 domain-containing protein | - |
| LY388_RS04750 (LY388_04750) | 1025476..1025601 | - | 126 | WP_230080128.1 | DUF3709 domain-containing protein | - |
| LY388_RS04755 (LY388_04755) | 1025727..1026263 | - | 537 | WP_234115907.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 992905..1075334 | 82429 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10838.56 Da Isoelectric Point: 4.6794
>T230548 WP_000578471.1 NZ_CP090386:1021046-1021324 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T230548 NZ_CP124921:2779642-2779785 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT230548 WP_000381183.1 NZ_CP090386:1020765-1021049 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT230548 NZ_CP124921:c2779979-2779717 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A271VKS2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |