Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 995154..995701 Replicon chromosome
Accession NZ_CP090386
Organism Vibrio cholerae strain GXFL1-4

Toxin (Protein)


Gene name relE Uniprot ID A0A0Q0PYS1
Locus tag LY388_RS04480 Protein ID WP_000229322.1
Coordinates 995154..995456 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag LY388_RS04485 Protein ID WP_000861987.1
Coordinates 995444..995701 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY388_RS04440 (LY388_04440) 990238..990609 + 372 WP_000401420.1 hypothetical protein -
LY388_RS04445 (LY388_04445) 990659..991018 + 360 WP_000290080.1 phage tail assembly protein -
LY388_RS04450 (LY388_04450) 991234..992163 + 930 Protein_886 tape measure protein -
LY388_RS04455 (LY388_04455) 992149..992844 + 696 WP_032472361.1 hypothetical protein -
LY388_RS04460 (LY388_04460) 992947..993141 - 195 Protein_888 hypothetical protein -
LY388_RS04465 (LY388_04465) 993292..993756 - 465 WP_057563742.1 GNAT family N-acetyltransferase -
LY388_RS04470 (LY388_04470) 993915..994454 - 540 WP_057563841.1 hydrolase -
LY388_RS04475 (LY388_04475) 994659..994805 - 147 WP_234115992.1 DUF645 family protein -
LY388_RS04480 (LY388_04480) 995154..995456 - 303 WP_000229322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LY388_RS04485 (LY388_04485) 995444..995701 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LY388_RS04490 (LY388_04490) 996404..996586 - 183 WP_148504768.1 DUF645 family protein -
LY388_RS04495 (LY388_04495) 996940..997112 - 173 Protein_895 DUF645 family protein -
LY388_RS04500 (LY388_04500) 997173..997313 - 141 Protein_896 acetyltransferase -
LY388_RS04505 (LY388_04505) 997893..998492 - 600 WP_057563830.1 glutathione S-transferase N-terminal domain-containing protein -
LY388_RS04510 (LY388_04510) 998732..998878 - 147 Protein_898 DUF645 family protein -
LY388_RS04515 (LY388_04515) 998939..999074 - 136 Protein_899 acetyltransferase -
LY388_RS04520 (LY388_04520) 999055..999174 - 120 WP_080004135.1 DUF3265 domain-containing protein -
LY388_RS04525 (LY388_04525) 999167..999868 - 702 WP_001162671.1 HNH endonuclease -
LY388_RS04530 (LY388_04530) 999898..1000008 - 111 WP_196389672.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 982167..1000912 18745
- inside Integron - - 992905..1075334 82429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11737.67 Da        Isoelectric Point: 5.1972

>T230546 WP_000229322.1 NZ_CP090386:c995456-995154 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T230546 NZ_CP124921:c2701383-2701240 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT230546 WP_000861987.1 NZ_CP090386:c995701-995444 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT230546 NZ_CP124921:2701121-2701266 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PYS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References