Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 966959..967469 | Replicon | chromosome |
| Accession | NZ_CP090386 | ||
| Organism | Vibrio cholerae strain GXFL1-4 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LY388_RS04260 | Protein ID | WP_199358682.1 |
| Coordinates | 966959..967222 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7Y3QZ95 |
| Locus tag | LY388_RS04265 | Protein ID | WP_001223794.1 |
| Coordinates | 967215..967469 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LY388_RS04210 (LY388_04210) | 962218..962397 | - | 180 | WP_199358724.1 | DUF645 family protein | - |
| LY388_RS04215 (LY388_04215) | 962697..963233 | - | 537 | WP_033931679.1 | GNAT family protein | - |
| LY388_RS04220 (LY388_04220) | 963383..963919 | - | 537 | WP_000644495.1 | nucleotidyltransferase family protein | - |
| LY388_RS04225 (LY388_04225) | 964171..964407 | + | 237 | WP_000772130.1 | RNA-binding protein | - |
| LY388_RS04230 (LY388_04230) | 964582..964941 | - | 360 | WP_001071521.1 | VOC family protein | - |
| LY388_RS04235 (LY388_04235) | 965117..965716 | - | 600 | WP_057563813.1 | outer membrane beta-barrel protein | - |
| LY388_RS04240 (LY388_04240) | 965884..966021 | - | 138 | Protein_844 | cell shape-determining protein MreC | - |
| LY388_RS04245 (LY388_04245) | 965996..966049 | - | 54 | Protein_845 | DUF645 family protein | - |
| LY388_RS04250 (LY388_04250) | 966172..966315 | - | 144 | Protein_846 | acetyltransferase | - |
| LY388_RS19775 | 966465..966617 | - | 153 | WP_262364168.1 | DUF645 family protein | - |
| LY388_RS04260 (LY388_04260) | 966959..967222 | - | 264 | WP_199358682.1 | Txe/YoeB family addiction module toxin | Toxin |
| LY388_RS04265 (LY388_04265) | 967215..967469 | - | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LY388_RS04270 (LY388_04270) | 967679..968104 | - | 426 | WP_000403003.1 | GNAT family N-acetyltransferase | - |
| LY388_RS04275 (LY388_04275) | 968199..968603 | - | 405 | WP_234115989.1 | hypothetical protein | - |
| LY388_RS04280 (LY388_04280) | 968677..968772 | - | 96 | WP_095472975.1 | DUF3265 domain-containing protein | - |
| LY388_RS04285 (LY388_04285) | 968911..969750 | - | 840 | WP_057563442.1 | HNH endonuclease | - |
| LY388_RS04290 (LY388_04290) | 969763..971259 | - | 1497 | WP_057563443.1 | AAA family ATPase | - |
| LY388_RS04295 (LY388_04295) | 971682..971789 | - | 108 | Protein_855 | acetyltransferase | - |
| LY388_RS04300 (LY388_04300) | 971794..971916 | - | 123 | WP_234115990.1 | DUF3265 domain-containing protein | - |
| LY388_RS04305 (LY388_04305) | 971921..972277 | - | 357 | WP_033838071.1 | DUF6404 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 940330..981769 | 41439 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10371.70 Da Isoelectric Point: 8.8576
>T230545 WP_199358682.1 NZ_CP090386:c967222-966959 [Vibrio cholerae]
MSSRLLSWTDESRDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY
MSSRLLSWTDESRDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITV
ISCRYHY
Download Length: 264 bp
>T230545 NZ_CP124921:c2701008-2700865 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9437.64 Da Isoelectric Point: 5.0481
>AT230545 WP_001223794.1 NZ_CP090386:c967469-967215 [Vibrio cholerae]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE
Download Length: 255 bp
>AT230545 NZ_CP124921:2701109-2701307 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|