Detailed information of TA system TA230543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 957962..958527
• Replicon: chromosome
• Accession: NZ_CP090386
• Organism: Vibrio cholerae strain GXFL1-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A271VGY0
• Locus tag: LY388_RS04165
• Protein ID: WP_000869987.1
• Coordinates: 957962..958249 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D0IIK3
• Locus tag: LY388_RS04170
• Protein ID: WP_000086649.1
• Coordinates: 958246..958527 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LY388_RS04135 (LY388_04135)	953177..953641	+	465	WP_057563740.1	hypothetical protein	-
LY388_RS04140 (LY388_04140)	953719..954018	-	300	WP_057563739.1	hypothetical protein	-
LY388_RS04145 (LY388_04145)	954162..954650	-	489	WP_234115897.1	hypothetical protein	-
LY388_RS04150 (LY388_04150)	954803..956110	-	1308	WP_057563836.1	DUF4325 domain-containing protein	-
LY388_RS04155 (LY388_04155)	956248..957174	-	927	WP_057563834.1	PD-(D/E)XK nuclease superfamily protein	-
LY388_RS04160 (LY388_04160)	957443..957739	-	297	Protein_828	DUF3709 domain-containing protein	-
LY388_RS04165 (LY388_04165)	957962..958249	-	288	WP_000869987.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LY388_RS04170 (LY388_04170)	958246..958527	-	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LY388_RS04175 (LY388_04175)	958735..959199	-	465	WP_057563827.1	ASCH domain-containing protein	-
LY388_RS04180 (LY388_04180)	959350..960102	-	753	WP_001035644.1	hypothetical protein	-
LY388_RS04185 (LY388_04185)	960257..960544	-	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LY388_RS04190 (LY388_04190)	960534..960785	-	252	WP_001250177.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LY388_RS04195 (LY388_04195)	961092..961469	+	378	WP_000734783.1	PEGA domain-containing protein	-
LY388_RS04200 (LY388_04200)	961650..961757	-	108	WP_080391616.1	Tfp pilus assembly protein	-
LY388_RS04205 (LY388_04205)	961741..961863	-	123	WP_057569709.1	DUF645 family protein	-
LY388_RS04210 (LY388_04210)	962218..962397	-	180	WP_199358724.1	DUF645 family protein	-
LY388_RS04215 (LY388_04215)	962697..963233	-	537	WP_033931679.1	GNAT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	940330..981769	41439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11031.76 Da
• Isoelectric Point: 6.0710

>T230543 WP_000869987.1 NZ_CP090386:c958249-957962 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIAFDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T230543 NZ_CP124921:c2629236-2629135 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10361.93 Da
• Isoelectric Point: 5.1548

>AT230543 WP_000086649.1 NZ_CP090386:c958527-958246 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT230543 NZ_CP124921:2629011-2629190 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Toxin

• AlphaFold DB: A0A271VGY0

Antitoxin

• AlphaFold DB: A0A0K9UIW4