230542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 943848..944407 Replicon chromosome
Accession NZ_CP090386
Organism Vibrio cholerae strain GXFL1-4

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag LY388_RS04060 Protein ID WP_000578471.1
Coordinates 944129..944407 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LY388_RS04055 Protein ID WP_000381183.1
Coordinates 943848..944132 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY388_RS04025 (LY388_04025) 939930..940330 - 401 Protein_801 type II toxin-antitoxin system death-on-curing family toxin -
LY388_RS04030 (LY388_04030) 940330..940500 - 171 WP_057569703.1 hypothetical protein -
LY388_RS04035 (LY388_04035) 941218..942176 + 959 Protein_803 IS30 family transposase -
LY388_RS04040 (LY388_04040) 942294..942566 + 273 WP_000246255.1 DUF1778 domain-containing protein -
LY388_RS04045 (LY388_04045) 942563..943060 + 498 WP_057563831.1 GNAT family N-acetyltransferase -
LY388_RS04050 (LY388_04050) 943217..943651 - 435 WP_057569701.1 GNAT family N-acetyltransferase -
LY388_RS04055 (LY388_04055) 943848..944132 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LY388_RS04060 (LY388_04060) 944129..944407 + 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LY388_RS04065 (LY388_04065) 944546..945184 - 639 WP_057563214.1 HD domain-containing protein -
LY388_RS04070 (LY388_04070) 945348..945971 - 624 WP_199358687.1 DUF1349 domain-containing protein -
LY388_RS04075 (LY388_04075) 946181..946363 - 183 WP_060780652.1 DUF645 family protein -
LY388_RS04080 (LY388_04080) 946658..947044 - 387 WP_001015867.1 NUDIX hydrolase -
LY388_RS04085 (LY388_04085) 947277..947729 + 453 WP_000024294.1 DUF2384 domain-containing protein -
LY388_RS04090 (LY388_04090) 947729..948199 + 471 WP_057563215.1 RES family NAD+ phosphorylase -
LY388_RS04095 (LY388_04095) 948340..948792 - 453 WP_053034773.1 HPP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 940330..981769 41439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T230542 WP_000578471.1 NZ_CP090386:944129-944407 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230542 NZ_CP124921:c2628803-2628702 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230542 WP_000381183.1 NZ_CP090386:943848-944132 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230542 NZ_CP124921:2628580-2628757 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References