Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 942294..943060 | Replicon | chromosome |
| Accession | NZ_CP090386 | ||
| Organism | Vibrio cholerae strain GXFL1-4 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | LY388_RS04045 | Protein ID | WP_057563831.1 |
| Coordinates | 942563..943060 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0Q0PQR2 |
| Locus tag | LY388_RS04040 | Protein ID | WP_000246255.1 |
| Coordinates | 942294..942566 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LY388_RS04025 (LY388_04025) | 939930..940330 | - | 401 | Protein_801 | type II toxin-antitoxin system death-on-curing family toxin | - |
| LY388_RS04030 (LY388_04030) | 940330..940500 | - | 171 | WP_057569703.1 | hypothetical protein | - |
| LY388_RS04035 (LY388_04035) | 941218..942176 | + | 959 | Protein_803 | IS30 family transposase | - |
| LY388_RS04040 (LY388_04040) | 942294..942566 | + | 273 | WP_000246255.1 | DUF1778 domain-containing protein | Antitoxin |
| LY388_RS04045 (LY388_04045) | 942563..943060 | + | 498 | WP_057563831.1 | GNAT family N-acetyltransferase | Toxin |
| LY388_RS04050 (LY388_04050) | 943217..943651 | - | 435 | WP_057569701.1 | GNAT family N-acetyltransferase | - |
| LY388_RS04055 (LY388_04055) | 943848..944132 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| LY388_RS04060 (LY388_04060) | 944129..944407 | + | 279 | WP_000578471.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| LY388_RS04065 (LY388_04065) | 944546..945184 | - | 639 | WP_057563214.1 | HD domain-containing protein | - |
| LY388_RS04070 (LY388_04070) | 945348..945971 | - | 624 | WP_199358687.1 | DUF1349 domain-containing protein | - |
| LY388_RS04075 (LY388_04075) | 946181..946363 | - | 183 | WP_060780652.1 | DUF645 family protein | - |
| LY388_RS04080 (LY388_04080) | 946658..947044 | - | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| LY388_RS04085 (LY388_04085) | 947277..947729 | + | 453 | WP_000024294.1 | DUF2384 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 940330..981769 | 41439 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18575.22 Da Isoelectric Point: 8.7753
>T230541 WP_057563831.1 NZ_CP090386:942563-943060 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPIVIVDAKDGAKHFYERYGFQAFQDAENKLFFTIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPIVIVDAKDGAKHFYERYGFQAFQDAENKLFFTIADI
RASLG
Download Length: 498 bp
>T230541 NZ_CP124921:2459201-2459854 [Enterococcus faecalis]
TTGATTGGACTGTTGTTGGTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAA
AGAAGTATCTTACTACTCTTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAG
ATGTTGAATTTGTTGAATACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAA
GTCATTATAGCAACAAACAAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATGCATTACTACAT
AGATATACCTAAAATTAATAATGCAACTCATACTTTTTCTGATATTCTTTTGAAAAATGGTTACTTGATGGAAGATTTTC
CAAAAGAATATCGTGCTAATGTCGGTGCTAGTATGTTAATGGCAAATGATCAAGCATTGTTTTACGCATTAAAAAAATTT
TATTCATTCGAAGAAATTGCACAATACTTTTTTATGAGCAAATCTGCATTAAGAAATAGACTCATCGAGCATCTTATGTA
TGTAAATAATTGTACTTTTGCACACGCTAATACACTTTTTAACAATTATTACTTTCATAAAGAAACTGATATCTACAGAT
TTATTTTCAATTAG
TTGATTGGACTGTTGTTGGTGGATTTTATTAGTAAAGAACTCTATTTTGAAGCATTTAATTTTTCGAACGAATTAATAAA
AGAAGTATCTTACTACTCTTCCAAAAATATTGAACAAGTTAAATGCTTTGATATTGAAAAATATGTAAAAGAAGTTGAAG
ATGTTGAATTTGTTGAATACACGTTTCAAAAACAACTTAAAAGACGGATGCTTGGTTCAATCTCTAAAGTAGACGATGAA
GTCATTATAGCAACAAACAAAGAATTAATGTTAGAACGAAAAAATTTCACTAAAATGCATGAGGTTATGCATTACTACAT
AGATATACCTAAAATTAATAATGCAACTCATACTTTTTCTGATATTCTTTTGAAAAATGGTTACTTGATGGAAGATTTTC
CAAAAGAATATCGTGCTAATGTCGGTGCTAGTATGTTAATGGCAAATGATCAAGCATTGTTTTACGCATTAAAAAAATTT
TATTCATTCGAAGAAATTGCACAATACTTTTTTATGAGCAAATCTGCATTAAGAAATAGACTCATCGAGCATCTTATGTA
TGTAAATAATTGTACTTTTGCACACGCTAATACACTTTTTAACAATTATTACTTTCATAAAGAAACTGATATCTACAGAT
TTATTTTCAATTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9713.24 Da Isoelectric Point: 6.2988
>AT230541 WP_000246255.1 NZ_CP090386:942294-942566 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT230541 NZ_CP124921:2458818-2459204 [Enterococcus faecalis]
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTGCACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTTAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAAATTGA
GTGACTATTATTAAAACAAATGAACGTTTGAAACAACTACGTGAAAATAAAGAATTAACTCAAAAAGAATTAGCTGATTT
ACTGCACATGGATAGAAGTGTTTATAATAAAATTGAATCAGGTGCTCGTCCCATTCGTGATAACGAACTAATTCAATTTG
CGGATTTCTATAATGTATCAACAGACTACCTTACAAATAGAACTAACAATCCCATTCCCCCTGAAGAAAAAACAAATGTG
GGACAAAATATCATCTCACATTTTCGTCTTAATACTTCTGATATGGACATAGAAGATATAGAAGAATTAGAAGAAGAATT
AATCGACTTTCAAGATTTTCTTATAAAAAAAGCAAAAGAAAAAAAGGAACGTAACAAAAAAAATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|