Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 59807..60335 | Replicon | plasmid p1_SCLZS30 |
| Accession | NZ_CP090385 | ||
| Organism | Acinetobacter towneri strain SCLZS30 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LZG54_RS14625 | Protein ID | WP_154320209.1 |
| Coordinates | 59807..60100 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | N9B5Q7 |
| Locus tag | LZG54_RS14630 | Protein ID | WP_000246756.1 |
| Coordinates | 60090..60335 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZG54_RS14570 (LZG54_14585) | 54901..55206 | - | 306 | Protein_45 | transposase | - |
| LZG54_RS14575 (LZG54_14590) | 55196..55627 | - | 432 | WP_005401805.1 | MarR family transcriptional regulator | - |
| LZG54_RS14580 (LZG54_14595) | 55690..56394 | - | 705 | WP_004733335.1 | IS6-like element IS1008 family transposase | - |
| LZG54_RS14585 (LZG54_14600) | 56453..56530 | + | 78 | Protein_48 | plasmid pRiA4b ORF-3 family protein | - |
| LZG54_RS14590 (LZG54_14605) | 56591..56905 | - | 315 | WP_004740255.1 | BrnA antitoxin family protein | - |
| LZG54_RS14595 (LZG54_14610) | 56868..57179 | - | 312 | WP_004761029.1 | BrnT family toxin | - |
| LZG54_RS14600 (LZG54_14615) | 57393..57863 | - | 471 | WP_039048355.1 | DUF1643 domain-containing protein | - |
| LZG54_RS14605 (LZG54_14620) | 57939..58484 | + | 546 | WP_234115075.1 | macro domain-containing protein | - |
| LZG54_RS14610 (LZG54_14625) | 58504..58890 | - | 387 | WP_161418651.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| LZG54_RS14615 (LZG54_14630) | 58887..59066 | - | 180 | WP_161418652.1 | hypothetical protein | - |
| LZG54_RS14620 (LZG54_14635) | 59384..59719 | - | 336 | WP_161418653.1 | hypothetical protein | - |
| LZG54_RS14625 (LZG54_14640) | 59807..60100 | - | 294 | WP_154320209.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZG54_RS14630 (LZG54_14645) | 60090..60335 | - | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LZG54_RS14635 (LZG54_14650) | 60494..60907 | + | 414 | WP_070155403.1 | hypothetical protein | - |
| LZG54_RS14640 (LZG54_14655) | 60910..61224 | + | 315 | WP_070155405.1 | hypothetical protein | - |
| LZG54_RS14645 (LZG54_14660) | 61418..61600 | - | 183 | WP_234115076.1 | hypothetical protein | - |
| LZG54_RS14650 (LZG54_14665) | 61642..62574 | + | 933 | WP_004812228.1 | IS5-like element ISAha3 family transposase | - |
| LZG54_RS14655 (LZG54_14670) | 62626..62757 | - | 132 | Protein_62 | IS3 family transposase | - |
| LZG54_RS14660 (LZG54_14675) | 63058..63252 | + | 195 | Protein_63 | recombinase family protein | - |
| LZG54_RS14665 (LZG54_14680) | 63315..64019 | + | 705 | WP_234115077.1 | IS6-like element IS1006 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | cmlB1 | - | 1..64918 | 64918 | |
| - | flank | IS/Tn | - | - | 55690..56394 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11354.64 Da Isoelectric Point: 10.5031
>T230540 WP_154320209.1 NZ_CP090385:c60100-59807 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPVAIREQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKY
MTYKLLRHKDFTAEWEKLPVAIREQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKY
Download Length: 294 bp
>T230540 NZ_CP124921:1801554-1801898 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTCTCCCATTCGGATTATATTGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATTAT
CATATGTTTAAATGTCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAATTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9235.61 Da Isoelectric Point: 4.3142
>AT230540 WP_000246756.1 NZ_CP090385:c60335-60090 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT230540 NZ_CP124921:1801205-1801537 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|